1109284-41-4

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1109284-40-3 (1S,6R)-6-amino-2,2-difluorocyclohexan-1-ol 
• 1109284-39-0 (1S,6R)-2,2-difluoro-6-[[(1R)-1-phenylethyl]amino]cyclohexanol 
• 6705-49-3 7-oxabicyclo[4.1.0]heptan-2-one 
• 1109284-38-9 2,2-difluoro-7-oxabicyclo[4.1.0]heptane 
• 6705-49-3 7-oxabicyclo[4.1.0]heptan-2-one 

Downstream Products

• 1207557-06-9 (1S,6R)-6-((tert-butoxycarbonyl)amino)-2,2-difluorocyclohexyl trifluoromethanesulfonate 
• 1439907-22-8 2-((1R,2R)-2-amino-3,3-difluorocyclohexylamino)-4-(quinolin-3-ylamino)pyrimidin-5-carboxamide 
• 1109284-37-8 tert-butyl N-[(1R,2R)-2-amino-3,3-difluorocyclohexyl]carbamate 
• 1439905-72-2 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-((1R,2R)-2-amino-3,3-difluorocyclohexylamino)pyrimidin-5-carboxamide 
• 1314893-26-9 N-((1R,6R)-6-amino-2,2-difluorocyclohexyl)-4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-methylthiophene-2-carboxamide 
• 1109284-45-8 tert-butyl N-[(1R,2R)-2-azido-3,3-difluorocyclohexyl]carbamate 

Relevant academic research and scientific papers

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties

Inhibition of microtubule affinity regulating kinase (MARK) represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer's disease. This manuscript outlines efforts to optimize a pyrazolopyrimidine series of MARK in

SELECTIVE KINASE INHIBITORS

Provided are pyrimidine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

PYRAZOLO[1,5-A]PYRIDINES AS MARK INHIBITORS

The invention encompasses pyrazolo[1,5-a]pyridine derivatives which selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease. Pharmaceutical compositions and methods of use are also included.

IMIDAZO[1,2-a]PYRIDINES AND IMIDAZO[1,2-b]PYRIDAZINES AS MARK INHIBITORS

The invention encompasses imidazo[1,2-a]pyridine and imidazo[1,2-b]pyridazine derivatives which selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease. Pharmaceutical compositions and methods of use are also included.

PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES

Compounds of the following formula (I) are inhibitors of microtubule affinity regulating kinase, and hence find use in the treatment of neurodegenerative diseases associated with hyperphosphorylation of tau.