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Usage

Uses

Used in Pharmaceutical Industry:
Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)furan-3-carboxylate is used as a reagent for the preparation of various pharmaceuticals. Its versatile reactivity allows for the synthesis of a wide range of biologically active compounds, making it a valuable component in drug development.
Used in Agrochemical Industry:
In the agrochemical industry, Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)furan-3-carboxylate is utilized as a building block for the synthesis of agrochemicals. Its ability to form various biologically active compounds contributes to the development of effective agricultural products.
Safety Precautions:
It is important to handle Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)furan-3-carboxylate with care due to its potential health hazards, including skin and eye irritation. Only individuals with proper training and protective equipment should use Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)furan-3-carboxylate to ensure safety during its application in various industries.

Upstream product

• 13129-23-2 methyl furan-3-carboxylate 
• 73183-34-3 bis(pinacol)diborane 
• 488-93-7 3-Furoic acid 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 1073354-94-5 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)furan-3-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 

Relevant academic research and scientific papers

Synthesis of Raputimonoindoles A–C and Congeners

The first synthesis of raputimonoindole A from the tree Raputia praetermissa (Rutaceae) is reported, starting from indole-5-carbaldehyde. The key step is Braun′s diastereoselective Heck–Suzuki cascade that assembled the prenylated methylenetetrahydrofuran moiety. The unsubstituted indole enamine functionality was tolerated, and the absolute configuration of naturally occurring raputimonoindole A is assigned as (R,R). Raputimonoindole B was accessed by Ir-catalyzed C–H activation/borylation followed by Suzuki–Miyaura cross-coupling. Two biosynthetically related 5-(dihydrofuran-2-yl)indole derivatives from R. simulans were synthesized by ring-closing metathesis, and their absolute configurations were determined.

Photostable Helical Polyfurans

This report describes the design and synthesis of a new class of polyfurans bearing ester side chains. The macromolecules can be synthesized using catalyst-transfer polycondensation, providing precise control over molecular weight and molecular weight distribution. Such obtained furan ester polymers are significantly more photostable than their alkyl analogues owing to the electron-withdrawing nature of the attached subunit. Most interestingly, they spontaneously fold into a compact π-stacked helix, yielding a complex multilayer cylindrical nanoparticle with a hollow, rigid, conjugated core composed of the polyfuran backbone and a soft, insulating outer layer formed by the ester side chains. The length of polymer side chains dictates the outer diameter of such nanoparticles, which for the hexyl ester groups used in the present study is equal to ～2.3 nm. The inner cavity of the conjugated core is lined with oxygen atoms, which set its effective diameter to 0.4 nm. Furthermore, installation of bulkier, branched chiral ester side chains on the repeat unit yields structures that, upon change of solvent, can reversibly transition between an ordered chiral helical folded and disordered unfolded state.

CYCLIC AMINE SUBSTITUTED OXAZOLIDINONE CETP INHIBITOR

CCompounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compound of Formula I, A3 is a substitiuted phenyl group or indanyl group.Formula (I)