111142-77-9Relevant academic research and scientific papers
Alkyl and carboxylalkyl esters of 4′-demethyl-4-deoxypodophyllotoxin: Synthesis, cytotoxic, and antitumor activity
You, Young-Jae,Kim, Yong,Nam, Nguyen-Hai,Bang, Seong-Cheol,Ahn, Byung-Zun
, p. 189 - 193 (2004)
Esters of 4′-demethyl-4-deoxypodophyllotoxin (DDPT) with alkanoic acids and alkanedioic acids were prepared and tested for cytotoxic and antitumor activity. Among 19 esters, esters of propanoic acid, tetradecanedioic acid, 13-carboxyundecanoic acid, and h
Immunosuppressive cyclolignans
Gordaliza, Marina,Faircloth, Glynn T.,Castro, Ma. Angeles,Miguel Del Corral, José M.,López-Vázquez, Ma. Luisa,San Feliciano, Arturo
, p. 2865 - 2868 (2007/10/03)
The immunosuppressive activity of several lactonic, nonlactonic, and heterocycle-fused cyclolignans has been demonstrated for the first time by use of a T-cell-mediated immune response. Of the compounds tested, 4'- demethyldeoxypodophyllotoxin (8), β-apopicropodophyllin (6), and the isoxazoline-fused cyclolignan 15 are the most potent with respect to their suppression of activated splenocytes.
