111205-30-2

Upstream product

• 111205-32-4 4-hydroxy-5,6,7,8-tetrahydro-quinoline-3-carboxylic acid ethyl ester 
• 58780-88-4 2-(cyclohex-1-enylaminomethylene)-malonic acid diethyl ester 
• 6296-99-7 diethyl aminomethylenemalonate 
• 58596-36-4 4-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid ethyl ester 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 108-94-1 cyclohexanone 

Downstream Products

• 102230-69-3 CGS 17867A 

Relevant academic research and scientific papers

ORGANIC COMPOUNDS

The invention relates to compound of the formula (I), in which R1 represents an optionally substituted aryl group or an optionally substituted heteroaryl group; R2 represents hydrogen or a substituent different from hydrogen; R3

2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: Functionally selective benzodiazepine binding site ligands on the GABAA receptor

2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones are GABAA receptor benzodiazepine binding site ligands with functional selectivity for the α3 subtype over the α1 subtype. SAR studies to optimise this functional selectivity are described.

Ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives as benzodiazepine receptor modulators

Compounds of the formula formula IA or IB STR1 wherein A represents an optionally substituted saturated divalent grouping which together with the two carbon atoms to which it is attached represents a fused 5-, 6- or 7-membered carbocyclic or heterocyclic ring selected from optionally substituted fused cyclopenteno, cyclohexeno, cyclohepteno, dihydrothieno, dihydrothiopyrano, tetrahydrothiepino, dihydrofuro, dihydropyrano, tetrahydrooxepino, dihydropyrrolo, tetrahydropyrido and tetrahydroazepino; R 1 represents lower alkyl, phenyl, or phenyl mono- or disubstituted by lower alkyl, lower alkoxy, halogen or trifluoromethyl; or R 1 represents an aromatic heterocyclic radical selected from e.g. optionally substituted pyridyl, quinolyl, isoquinolyl, pyrimidyl and thiazolyl; R 2, R 3, R 3 '' are hydrogen or lower alkyl; and pharmaceutically acceptable salts; are useful as benzodiazepine receptor modulators for the treatment of nervous system disorders. Pharmaceutical compositions, methods of preparation and certain intermediates useful as benzodiazepine receptor modulators are also disclosed.