58780-88-4Relevant academic research and scientific papers
2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: Functionally selective benzodiazepine binding site ligands on the GABAA receptor
Mitchinson, Andrew,Atack, John R.,Blurton, Peter,Carling, Robert W.,Castro, Jose L.,Curley, Karen S.,Russell, Michael G. N.,Marshall, George,McKernan, Ruth M.,Moore, Kevin W.,Narquizian, Robert,Smith, Alison,Street, Leslie J.,Thompson, Sally-Anne,Wafford, Keith
, p. 3441 - 3444 (2004)
2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones are GABAA receptor benzodiazepine binding site ligands with functional selectivity for the α3 subtype over the α1 subtype. SAR studies to optimise this functional selectivity are described.
Hydroxy cycloalkyl fused pyridone carboxylic acid M1 positive allosteric modulators
Kuduk, Scott D.,DiPardo, Robert M.,Beshore, Douglas C.,Ray, William J.,Ma, Lei,Wittmann, Marion,Seager, Matthew A.,Koeplinger, Kenneth A.,Thompson, Charles D.,Hartman, George D.,Bilodeau, Mark T.
scheme or table, p. 2538 - 2541 (2010/08/05)
Incorporation of hydroxycycloalkyl fused pyridone carboxylic acids in lieu of quinolone carboxylic acids enhance free fraction without increased susceptibility to P-glycoprotein transport.
ORGANIC COMPOUNDS
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Page/Page column 19, (2009/04/25)
The invention relates to compound of the formula (I), in which R1 represents an optionally substituted aryl group or an optionally substituted heteroaryl group; R2 represents hydrogen or a substituent different from hydrogen; R3
