1112982-79-2

Basic information

• Product Name: N-(5-bromo-2-chloro-3-pyridinyl)-4-fluoro-N-((4-fluorophenyl)sulfonyl)benzenesulfonamide
• Synonyms: N-(5-bromo-2-chloro-3-pyridinyl)-4-fluoro-N-((4-fluorophenyl)sulfonyl)benzenesulfonamide
• CAS NO: 1112982-79-2
• Molecular Weight: 523.763
• Mol File: 1112982-79-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(5-bromo-2-chloro-3-pyridinyl)-4-fluoro-N-((4-fluorophenyl)sulfonyl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-bromo-2-chloro-3-pyridinyl)-4-fluoro-N-((4-fluorophenyl)sulfonyl)benzenesulfonamide(1112982-79-2)
• EPA Substance Registry System: N-(5-bromo-2-chloro-3-pyridinyl)-4-fluoro-N-((4-fluorophenyl)sulfonyl)benzenesulfonamide(1112982-79-2)

Safety Data

• Hazardous Substances Data: 1112982-79-2(Hazardous Substances Data)

Upstream product

• 588729-99-1 3-amino-5-bromo-2-chloropyridine 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 

Downstream Products

• 1112980-86-5 N-(2-chloro-5-(2-acetylaminobenzo[d]thiazol-6-yl)pyridin-3-yl)-4-fluorophenylsulfonamide 
• 1201844-32-7 N-(2-chloro-5-(3-(pyridin-4-yl)quinoxalin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1201842-02-5 N-(2-chloro-5-(3-morpholinoquinoxalin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1312448-32-0 N-(2-chloro-5-(3-(dimethylamino)quinoxalin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1201845-24-0 N-(2-chloro-5-(3-chloroquinoxalin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1201843-95-9 N-(2-chloro-5-(4-(4-(dimethylamino)phenyl)quinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1312448-31-9 N-(2-chloro-5-(4-(pyridin-4-yl)quinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1201843-77-7 N-(2-chloro-5-(4-(pyridin-3-yl)quinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1201842-37-6 N-(2-chloro-5-(4-phenylquinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1201842-19-4 N-(5-4-((4-benzylpiperiazin-1-yl)quinolin-6-yl)-2-chloropyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1201842-13-8 N-(2-chloro-5-(4-(4-isopropylpiperazin-1-yl)quinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1201842-17-2 N-(2-chloro-5-(4-(4-hydroxypiperidin-1-yl)quinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1201842-11-6 N-(2-chloro-5-(4-(piperidin-1-yl)quinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1201843-67-5 N-(2-chloro-5-(4-(4-(pyridin-4-ylmethyl)piperazin-1-yl)quinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 

Relevant articles and documents

Phospshoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: Discovery and structure-activity relationships of a series of quinoline and quinoxaline derivatives

The phosphoinositide 3-kinase (PI3K) family catalyzes the ATP-dependent phosphorylation of the 3′-hydroxyl group of phosphatidylinositols and plays an important role in cell growth and survival. There is abundant evidence demonstrating that PI3K signaling is dysregulated in many human cancers, suggesting that therapeutics targeting the PI3K pathway may have utility for the treatment of cancer. Our efforts to identify potent, efficacious, and orally available PI3K/mammalian target of rapamycin (mTOR) dual inhibitors resulted in the discovery of a series of substituted quinolines and quinoxalines derivatives. In this report, we describe the structure-activity relationships, selectivity, and pharmacokinetic data of this series and illustrate the in vivo pharmacodynamic and efficacy data for a representative compound.

PI3 KINASE MODULATORS AND METHODS OF USE

The present invention comprises a new class of compounds capable of modulating the activity of PI3 kinase and, accordingly, useful for treatment of PI3 kinase mediated diseases, including melanomas, carcinomas and other cancer-related conditions. The compounds have a general Formula I wherein each of A1, A2, A3, A4, X, R1 and R2 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of PI3 kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.