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1112980-86-5

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1112980-86-5 Usage

General Description

N-[6-[6-Chloro-5-[[(4-fluorophenyl)sulfonyl]aMino]-3-pyridinyl]-1,3-benzothiazol-2-yl]acetaMide is a chemical compound that belongs to the class of acetamide derivatives. It contains a benzothiazole ring and a pyridine ring, as well as a sulfonyl amino group and a fluorophenyl substituent. N-[6-[6-Chloro-5-[[(4-fluorophenyl)sulfonyl]aMino]-3-pyridinyl]-1,3-benzothiazol-2-yl]acetaMide has potential pharmaceutical applications, particularly in the development of new drugs for various medical conditions. The specific biological and chemical properties of this compound may make it useful for further research and development in the pharmaceutical industry.

Check Digit Verification of cas no

The CAS Registry Mumber 1112980-86-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,1,2,9,8 and 0 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1112980-86:
(9*1)+(8*1)+(7*1)+(6*2)+(5*9)+(4*8)+(3*0)+(2*8)+(1*6)=135
135 % 10 = 5
So 1112980-86-5 is a valid CAS Registry Number.

1112980-86-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[6-(6-Chloro-5-{[(4-fluorophenyl)sulfonyl]amino}-3-pyridinyl)-1 ,3-benzothiazol-2-yl]acetamide

1.2 Other means of identification

Product number -
Other names N-(6-(<(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)-methyl>-amino)nicotinoyl)-gluta-minsaeure 3'-Aza-folsaeure

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1112980-86-5 SDS

1112980-86-5Downstream Products

1112980-86-5Relevant articles and documents

Discovery and optimization of a series of benzothiazole phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors

D'Angelo, Noel D.,Kim, Tae-Seong,Andrews, Kristin,Booker, Shon K.,Caenepeel, Sean,Chen, Kui,D'Amico, Derin,Freeman, Dan,Jiang, Jian,Liu, Longbin,McCarter, John D.,San Miguel, Tisha,Mullady, Erin L.,Schrag, Michael,Subramanian, Raju,Tang, Jin,Wahl, Robert C.,Wang, Ling,Whittington, Douglas A.,Wu, Tian,Xi, Ning,Xu, Yang,Yakowec, Peter,Yang, Kevin,Zalameda, Leeanne P.,Zhang, Nancy,Hughes, Paul,Norman, Mark H.

, p. 1789 - 1811 (2011/05/16)

Phosphoinositide 3-kinase α (PI3K-α) is a lipid kinase that plays a key regulatory role in several cellular processes. The mutation or amplification of this kinase in humans has been implicated in the growth of multiple tumor types. Consequently, PI3K- has become a target of intense research for drug discovery. Our studies began with the identification of benzothiazole compound 1 from a high throughput screen. Extensive SAR studies led to the discovery of sulfonamide 45 as an early lead, based on its in vitro cellular potency. Subsequent modifications of the central pyrimidine ring dramatically improved enzyme and cellular potency and led to the identification of chloropyridine 70. Further arylsulfonamide SAR studies optimized in vitro clearance and led to the identification of 82 as a potent dual inhibitor of PI3K and mTOR. This molecule exhibited potent enzyme and cell activity, low clearance, and high oral bioavailability. In addition, compound 82 demonstrated tumor growth inhibition in U-87 MG, A549, and HCT116 tumor xenograft models.

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