111400-50-1

Basic information

• Product Name: ethyl 2-benzoyl-2-methyl-4-oxo-4-phenylbutanoate
• Synonyms: ethyl 2-benzoyl-2-methyl-4-oxo-4-phenylbutanoate
• CAS NO: 111400-50-1
• Molecular Weight: 324.376
• Mol File: 111400-50-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 2-benzoyl-2-methyl-4-oxo-4-phenylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-benzoyl-2-methyl-4-oxo-4-phenylbutanoate(111400-50-1)
• EPA Substance Registry System: ethyl 2-benzoyl-2-methyl-4-oxo-4-phenylbutanoate(111400-50-1)

Safety Data

• Hazardous Substances Data: 111400-50-1(Hazardous Substances Data)

Upstream product

• 97-63-2 methyl methacrylate 
• 611-73-4 Benzoylformic acid 
• 70-11-1 α-bromoacetophenone 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 29113-48-2 ethyl 2-benzoyl-4-oxo-4-phenylbutanoate 
• 74-88-4 methyl iodide 

Downstream Products

• 111400-73-8 3-Methyl-2,5-diphenyl-pyrrole-1-carboxylic acid ethyl ester 
• 111400-69-2 ethyl 4-methyl-2,5-diphenyl-1H-pyrrole-3-carboxylate 
• 111400-54-5 2-Hydroxy-3-methyl-2,5-diphenyl-3,4-dihydro-2H-pyrrole-3-carboxylic acid ethyl ester 
• 111400-58-9 5-Hydroxy-3-methyl-2,5-diphenyl-4,5-dihydro-3H-pyrrole-3-carboxylic acid ethyl ester 
• 111400-62-5 3-Methyl-2,5-diphenyl-3H-pyrrole-3-carboxylic acid ethyl ester 

Relevant articles and documents

Direct 1,2-Dicarbonylation of Alkenes towards 1,4-Diketones via Photocatalysis

1,4-Dicarbonyl compounds are intriguing motifs and versatile precursors in numerous pharmaceutical molecules and bioactive natural compounds. Direct incorporation of two carbonyl groups into a double bond at both ends is straightforward, but also challenging. Represented herein is the first example of 1,2-dicarbonylation of alkenes by photocatalysis. Key to success is that N(n-Bu)4+ not only associates with the alkyl anion to avoid protonation, but also activates the α-keto acid to undergo electrophilic addition. The α-keto acid is employed both for acyl generation and electrophilic addition. By tuning the reductive and electrophilic ability of the acyl precursor, unsymmetric 1,4-dicarbonylation is achieved for the first time. This metal-free, redox-neutral and regioselective 1,2-dicarbonylation of alkenes is executed by a photocatalyst for versatile substrates under extremely mild conditions and shows great potential in biomolecular and drug molecular derivatization.