29113-48-2Relevant academic research and scientific papers
A new strategy for the synthesis of α,β-diaroylpropionates promoted by samarium metal in DMF
Liu, Yongjun,Liu, Xi,Zhang, Yongmin
, p. 1667 - 1670 (2003)
When promoted by samarium in DMF, aroyl chlorides react readily with acrylates to afford α,β-diaroylpropionates in good to excellent yields without pretreating or activating the metallic samarium.
Enantioselective Synthesis of Nitrogen-Nitrogen Biaryl Atropisomers via Copper-Catalyzed Friedel-Crafts Alkylation Reaction
Guo, Chang-Qiu,Liu, Ren-Rong,Lu, Chuan-Jun,Wang, Xiao-Mei,Xu, Qi,Zhang, De-Bing,Zhang, Peng
supporting information, p. 15005 - 15010 (2021/09/30)
Nitrogen-nitrogen bonds containing motifs are ubiquitous in natural products and bioactive compounds. However, the atropisomerism arising from a restricted rotation around an N-N bond is largely overlooked. Here, we describe a method to access the first enantioselective synthesis of N-N biaryl atropisomers via a Cu-bisoxazoline-catalyzed Friedel-Crafts alkylation reaction. A wide range of axially chiral N-N bisazaheterocycle compounds were efficiently prepared in high yields with excellent enantioselectivities via desymmetrization and kinetic resolution. Heating experiments showed that the axially chiral bisazaheterocycle products have high rotational barriers.
Electrochemical Synthesis of 1-Naphthols by Intermolecular Annulation of Alkynes with 1,3-Dicarbonyl Compounds
He, Mu-Xue,Mo, Zu-Yu,Wang, Zi-Qiang,Cheng, Shi-Yan,Xie, Ren-Ren,Tang, Hai-Tao,Pan, Ying-Ming
supporting information, p. 724 - 728 (2020/01/31)
C-centered radical cyclization under electrochemical conditions is a feasible strategy for constructing cyclic structures. Reported herein is the electrochemical synthesis of highly functionalized 1-naphthols using alkynes and 1,3-dicarbonyl compounds by
Heterogeneous synthesis of 1,4-enediones and 1,4-diketones with manganese oxide molecular sieves OMS-2 as a recyclable catalyst
Meng, Xu,Zhang, Jinqi,Chen, Gexin,Chen, Baohua,Zhao, Peiqing
, p. 239 - 242 (2015/07/27)
An efficient manganese oxide octahedral molecular sieves OMS-2-catalyzed chemoselective synthesis of 1,4-enediones and 1,4-diketones from 1,3-dicarbonyls and α-iodoacetophenones is described. The present catalytic system can be applied in one-pot, three-c
The rearrangement of tert -butylperoxides for the construction of polysubstituted furans
Zheng, Xiaojian,Lu, Shenglin,Li, Zhiping
supporting information, p. 5432 - 5435 (2013/11/19)
The Bronsted acid catalyzed rearrangement of tert-butyl peroxides provides a new strategy to construct 2,3-disubstituted furans via 1,2-aryl migration. In addition, tert-butyl peroxides could also be transformed into 2,3,5-trisubstituted or 2,5-disubstituted furans through a sequence of base-catalyzed Kornblum-DelaMare rearrangements and acid-promoted Paal-Knorr reactions.
INHIBITORS OF HISTONE DEACETYLASE
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Page/Page column 91, (2009/06/27)
ABSTRACT OF THE DISCLOSURE This invention relates to compounds and methods for the inhibition of HDAC enzymatic activity. More particularly, the invention provides for compounds of formula (I), (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein L, M, n, R, W, X and Y are as defined in the specification.
Cerium-catalyzed, aerobic oxidative synthesis of 1,2-dioxane derivatives from styrene and their fragmentation into 1,4-dicarbonyl compounds
Roessle, Michael,Werner, Thomas,Frey, Wolfgang,Christoffers, Jens
, p. 5031 - 5038 (2007/10/03)
1,4-Diketones were prepared by cerium-catalyzed oxidative coupling of styrene with molecular oxygen and 1,3-dicarbonyl compounds. This two-step sequence was performed as a one-pot procedure without isolation of the intermediate products. The first step is
Formation of 1,4-diketones via bis-acylation of the conjugated carbon-carbon double bonds in acrylates, acrylamides, methyl vinyl ketone and styrenes with aroyl chlorides promoted by samarium metal in DMF
Liu, Yongjun,Zhang, Yongmin
, p. 8429 - 8437 (2007/10/03)
Promoted by samarium in DMF, aroyl chlorides react readily with conjugated carbon-carbon double bonds in acrylates, acrylamides, methyl vinyl ketone and styrenes in a bis-acylation manner. These reactions proceed smoothly under mild conditions without the need of pretreating or activating the metallic samarium, affording the corresponding 1,4-diketones in good to excellent yields.
Olefin-insertion reaction between the carbonyls of benzils; formation of 1,4-diketones by Michael Additon catalyzed by Cyanide Ion
Miyashita, Akira,Numata, Atsushi,Suzuki, Yumiko,Iwamoto, Ken-Ichi,Higashino, Takeo
, p. 697 - 698 (2007/10/03)
Benzils (1) react with Michael addition acceptors (2) in the presence of cyanide ion as a catalyst to give 1,4-diketones (3), which are products of ethy lene group insertion between the carhonyls of the benzils. The 1,4-diketones (3) are produced through
THE SYNTHESIS AND CHEMISTRY OF AZOLENINES. PART 18. PREPARATION OF 3-ETHOXYCARBONYL-3H-PYRROLES VIA THE PAAL-KNORR REACTION, AND SIGMATROPIC REARRANGEMENTS INVOLVING COMPETITIVE ESTER MIGRATIONS TO C-2, C-4 AND N.
Chiu, Pak-Han,Sammes, Michael P.
, p. 3439 - 3456 (2007/10/02)
3H-Pyrrole-3-carboxylic esters (4) have been prepared, in some cases together with isomers (5) and (6) having exocyclic double bonds, by cyclization of suitably substituted 2-ethoxycarbonyl-1,4-diketones (1) with liquid ammonia, followed by dehydration of the isolable 2-hydroxy-3,4-dihydro-2H-pyrrole intermediates (2) and (3) with aluminia in boiling solvents.Prolonged heating in toluene or p-xylene converts the 3H-pyrroles (4) quantitatively into isomeric 4-esters (11) and N-esters (13) of 1H-pyrroles via competitive sigmatropic rearrangements.Isolable intermediate 2H-pyrrole-2-carboxylic esters (12) are converted similarly into the same products, under the same conditions.Detection of 3H-pyrroles (4) as intermediates in the latter reaction demonstrates for the first time the reversibility of the thermal 2H-pyrrole to 3H-pyrrole interconversion.
