1114561-85-1

Usage

Uses

Used in Pharmaceutical Industry:
(S)-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one is used as a potential candidate for the development of new pharmaceuticals due to its complex molecular structure containing functional groups often found in biologically active molecules. (S)-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one's specific chemical properties, including solubility, reactivity, and stability, would need further investigation to explore its possible applications and effects in the medical field.
Used in Chemical Research:
In the field of chemical research, (S)-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one serves as a subject for studying the effects of stereochemistry on molecular interactions and reactivity. Understanding these properties can contribute to the advancement of synthetic chemistry and the design of novel molecules with specific biological activities.

Upstream product

• 74-88-4 methyl iodide 
• 1110641-70-7 (S)-3-((S)-1-(4-bromophenyl)ethyl)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-1,3-oxazinan-2-one 
• 1110642-43-7 (S)-3-((S)-1-(4-bromophenyl)ethyl)-6-(2-oxopropyl)-6-phenyl-1,3-oxazinan-2-one 
• 1110642-01-7 (R)-6-allyl-3-((S)-1-(4-bromophenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one 
• 1110642-44-8 3-((R)-3-((S)-1-(4-bromophenyl)ethyl)-2-oxo-6-phenyl-1,3-oxazinan-6-yl)propanal 
• 1383540-76-8 phenyl (S)-3,5-dihydroxy-5-methyl-3-phenylhexyl-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)carbamate 
• 144741-40-2 3-methyl-1-phenyl-3-(trimethylsilyloxy)butan-1-one 
• 43108-74-3 3-hydroxy-3-methyl-1-phenyl-1-butanone 
• 98-86-2 acetophenone 
• 1351413-50-7 (1-methyl-2-oxo-1,2-dihydropyridin-4-yl)boronic acid 
• 214342-63-9 4-bromo-1-methyl-1,2-dihydropyridin-2-one 
• 1110642-47-1 (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborol-an-2-yl)phenyl)ethyl)-1,3-oxazinan-2-one 
• 889865-47-8 4-iodo-1-methyl-1,2-dihydropyridin-2-one 
• 636581-68-5 1-methyl-2-oxo-1,2-dihydropyrdin-4-yl trifluoromethanesulfonate 

Relevant academic research and scientific papers

Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor

A potent, in vivo efficacious 11β hydroxysteroid dehydrogenase type 1 (11β HSD1) inhibitor (11j) has been identified. Compound 11j inhibited 11β HSD1 activity in human adipocytes with an IC50 of 4.3?nM and in primary human adipose tissue with an IC80 of 53?nM. Oral administration of 11j to cynomolgus monkey inhibited 11β HSD1 activity in adipose tissue. Compound 11j exhibited >1000× selectivity over other hydroxysteroid dehydrogenases, displays desirable pharmacodynamic properties and entered human clinical trials in 2011.

METHODS OF MAKING DIASTEREOMERIC ORGANIC COMPOUNDS

Disclosed is a process for making diastereomeric compound of the formula (I): wherein m, n and R1 to R4 are as defined herein. The process of the invention provides the compound of formula (I) in high yield and substantially free of

2-OXO-1,2-DIHYDROPYRIDIN-4-YLBORONIC ACID DERIVATIVES

The present invention relates to a compound of formula (I) wherein R1, R2 and n are as defined herein. The invention also relates to processes for making the compounds of formula (I) and methods of using the compounds of formula (I)

CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1

This invention relates to novel compounds of the Formula Ik, Im1, Im2, Im5, In1, In2, In5, Io1, Io2, Io5, Ip1, Ip3, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.