111492-86-5

Basic information

• Product Name: N_b-benzyl-1,2,3,4-tetrahydro-β-carbolin-1-one
• Synonyms: N_b-benzyl-1,2,3,4-tetrahydro-β-carbolin-1-one
• CAS NO: 111492-86-5
• Molecular Weight: 276.338
• Mol File: 111492-86-5.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: N_b-benzyl-1,2,3,4-tetrahydro-β-carbolin-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: N_b-benzyl-1,2,3,4-tetrahydro-β-carbolin-1-one(111492-86-5)
• EPA Substance Registry System: N_b-benzyl-1,2,3,4-tetrahydro-β-carbolin-1-one(111492-86-5)

Safety Data

• Hazardous Substances Data: 111492-86-5(Hazardous Substances Data)

Upstream product

• 100-63-0 phenylhydrazine 
• 111492-69-4 1-(phenylmethyl)-2,3-piperidinedione 
• 15741-79-4 N-benzyl tryptamine 
• 61-54-1 tryptamine 
• 100-52-7 benzaldehyde 
• 201230-82-2 carbon monoxide 
• 19365-08-3 3-hydroxypiperidin-2-one 
• 111492-67-2 1-benzyl-3-benzyloxy-2-piperidone 
• 111492-68-3 3-hydroxy-1-benzyl-2-piperidinone 
• 16867-04-2 dihydroxypyridine 
• 111492-78-5 1-benzyl-3-phenylhydrazono-2-piperidone 
• 6250-88-0 4,9-Dihydropyrano<3,4-b>indol-1(3H)-on 
• 100-46-9 benzylamine 
• 2905-56-8 N-Benzylpiperidine 

Downstream Products

• 47064-53-9 2,3,4,9-Tetrahydro-2-(2-phenylmethyl)-1H-pyrido<3,4-b>indole 
• 1161933-48-7 2-benzyl-2,3,4,9-tetrahydro-β-carboline-1-thione 
• 1355045-73-6 (2-benzyl-1-thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acid t-butyl ester 
• 1161933-00-1 (2-benzyl-1-thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acid 

Relevant articles and documents

A mild Bischler–Napieralski-type cyclization of trichloromethyl carbamates for the synthesis of β -carbolinones

– A straightforward synthesis of β-carbolinones by the Bischler–Napieralski-type cyclization of the corresponding trichloromethyl carbamates, which does not require acids, bases, oxidants, or transition-metals to promote the cyclization, has been achieved.

Pd/Cu Cocatalyzed Oxidative Tandem C-H Aminocarbonylation and Dehydrogenation of Tryptamines: Synthesis of Carbolinones

The Pd/Cu cocatalyzed oxidative tandem C-H aminocarbonylation and dehydrogenation was developed, affording carbolinones with molecular oxygen as the terminal oxidant. Natural product strychnocarpine and its derivatives were prepared conveniently using this strategy.

Method for synthesizing tetrahydro beta-carboline-1-one compound through palladium catalysis

The invention discloses a method for synthesizing a tetrahydro beta-carboline-1-one compound through palladium catalysis. According to the method, carbonic oxide is used as a carbonyl source; the carbonic oxide and a tryptamine type compound react at ordinary pressure for efficiently preparing the tetrahydro beta-carboline-1-one compound. The method has the advantages that the tetrahydro beta-carboline-1-one compound with great application prospects is effectively prepared by using the carbonic oxide at the ordinary pressure as the carbonyl source and using bivalent metal palladium as a catalyst. From the angle of production and economy, through being compared with high-pressure reaction, the method has the advantages that the reaction cost is greatly reduced through carbonic oxide gas at normal temperature, and the reaction operability is improved.