111761-72-9

Upstream product

• 111761-71-8 (2R,3'S,5S,5'R)-benzyl 1-formyl-2',2'-dimethyl-4-oxo-5-phenylspiro-3'-carboxylate 
• 40514-98-5 (6S)-benzyl 6-amino-6-(methylthio)penicillanate 
• 111761-69-4 (6S)-benzyl 6-<(R)-2-azido-2-phenylacetamido>-6-(methylthio)penicillanate 
• 111761-71-8 (2R,3'S,5R,5'R)-benzyl 1-formyl-2',2'-dimethyl-4-oxo-5-phenylspiro-3'-carboxylate 
• 111821-10-4 (6S)-benzyl 6-<(R)-2-amino-2-phenylacetamido>-6-(methylthio)penicillanate 
• 111761-70-7 (2R,3'S,5R,5'R)-benzyl 2',2'-dimethyl-4-oxo-5-phenylspiro-3'-carboxylate 
• 35353-41-4 (R)-2-azido-2-phenylacetyl chloride 
• 29125-25-5 (R)-2-azido-2-phenylacetic acid 
• 111821-11-5 (6S)-benzyl 6-<(S)-2-amino-2-phenylacetamido>-6-(methylthio)penicillanate 
• 111761-70-7 (2R,3'S,5S,5'R)-benzyl 2',2'-dimethyl-4-oxo-5-phenylspiro-3'-carboxylate 

Relevant academic research and scientific papers

Spirocyclic Penicillins

The intramolecular, mercury-mediated cyclisation of (6S)-benzyl 6--6-(methylthio)penicillinates, (8) and (9), has been shown to give spiro derivatives.Unexpectedly, products (16) and (17), derived from attack on the more-hindered β-face, were isolated in addition to the predicted products (10) and (11), formed by attack on the α-face.Formylation and removal of the carboxy protecting group gave spirocyclic penicillins devoid of useful antibacterial activity.