111900-63-1Relevant academic research and scientific papers
GUANIDINE DERIVATIVES AS TRPC MODULATORS
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Page/Page column 134-135, (2014/02/16)
The present invention is directed to guanidine derivatives as inhibitors of transient receptor potential canonical channels (TRPC channels), in particular TRPC3 and/or TRPC6 and/or TRPC7 activity, more particularly TRPC6 activity. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders mediated by TRPC channels (Formula (I))
Regioselective alkylation of lithium dienediolates of α,β- unsaturated carboxylic acids
Brun, Eva M.,Gil, Salvador,Mestres, Ramón,Parra, Margarita
, p. 1160 - 1165 (2007/10/03)
Lithium carboxylic acids dienediolates are regioselectively alkylated at the α-carbon by reaction with tosylates derived from both primary and secondary alcohols. Both regio- and diastereoselectivity are improved when compared with those obtained in the c
Lithium enediolates and dienediolates of carboxylic acids in synthesis: Alkylation with secondary halides
Brun, Eva M.,Gil, Salvador,Mestres, Ramon,Parra, Margarita
, p. 15305 - 15320 (2007/10/03)
High yields in the alkylation of dianions of α,β-unsaturated carboxylic acids with secondary halides can be obtained despite elimination reactions occurring. α-Regioselectivity for the alkylation of but-2-enoic acids (1-4) is seldom obtained. Although dou
CATALYTIC ASYMMETRIC HYDROGENATION OF β-DISUBSTITUTED α-PHENYLACRYLIC ACIDS. ASYMMETRIC SYNTHESIS OF CARBOXYLIC ACIDS CONTAINING TWO VICINAL CHIRAL CARBON CENTERS
Hayashi, Tamio,Kawamura, Norio,Ito, Yoshihiko
, p. 5969 - 5972 (2007/10/02)
Hydrogenation of trisubstituted acrylic acids ((E)- and (Z)-MeC(R)=CPhCOOH: R = CD3, Et, Ph) in the presence of a chiral (aminoalkyl)ferrocenylphosphine-rhodium catalyst installed asymmetric configurations at two vicinal carbons at once giving optically a
