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1459-15-0

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1459-15-0 Usage

General Description

(R)-1-Phenyl-1-chloroethane, also known as phenylchloroethane, is a chemical compound with the molecular formula C8H9Cl. It is a colorless liquid with a sweet odor that is slightly soluble in water. (R)-1-Phenyl-1-chloroethane is mainly used as an intermediate in the production of pharmaceuticals, fragrances, and other organic compounds. It is also used as a solvent in various chemical processes. (R)-1-Phenyl-1-chloroethane is considered to have low to moderate toxicity and should be handled with caution due to its potential health hazards if inhaled, ingested, or absorbed through the skin. It is classified as a hazardous substance and should be stored, handled, and disposed of in accordance with safety regulations and guidelines.

Check Digit Verification of cas no

The CAS Registry Mumber 1459-15-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,5 and 9 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1459-15:
(6*1)+(5*4)+(4*5)+(3*9)+(2*1)+(1*5)=80
80 % 10 = 0
So 1459-15-0 is a valid CAS Registry Number.

1459-15-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (R)-1-chloro-1-phenylethane

1.2 Other means of identification

Product number -
Other names Benzene, (1-chloroethyl)-, (R)-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1459-15-0 SDS

1459-15-0Relevant articles and documents

Mechanical resolution of 1-phenylethyl 2-pyridyl sulfide and determination of its absolute configuration

Furukawa,Kawai,Oae,Iwasaki

, p. 746 - 747 (1984)

-

Formamide-Catalyzed Nucleophilic Substitutions: Mechanistic Insight and Rationalization of Catalytic Activity

Hilt, Gerhard,Huy, Peter H.,Kohlmeyer, Corinna,Sch?fer, André

, p. 11567 - 11577 (2020/11/17)

Herein, detailed mechanistic investigations into formamide-catalyzed nucleophilic substitution (SN) of alcohols are reported. Alkoxyiminium chlorides and hexafluorophosphates were synthesized and characterized as a key intermediate of the catalytic cycle. The determination of reaction orders and control experiments indicated that the nucleophilic attack of the formamide catalyst onto the reagent BzCl is the rate-determining step. Linear free energy relationship revealed a correlation between the quantified Lewis basicity strength of formamides by means of 11B NMR spectroscopy and their catalytic activity in SN-transformations. The observed difference in catalytic ability was attributed to the natural bond order charge, dipole moment, and Sterimol parameter B5. Importantly, this rationalization enables the prediction of the capacity of formamides to promote SN-type transformations in general.

A General Catalytic Method for Highly Cost- and Atom-Efficient Nucleophilic Substitutions

Huy, Peter H.,Filbrich, Isabel

supporting information, p. 7410 - 7416 (2018/04/30)

A general formamide-catalyzed protocol for the efficient transformation of alcohols into alkyl chlorides, which is promoted by substoichiometric amounts (down to 34 mol %) of inexpensive trichlorotriazine (TCT), is introduced. This is the first example of a TCT-mediated dihydroxychlorination of an OH-containing substrate (e.g., alcohols and carboxylic acids) in which all three chlorine atoms of TCT are transferred to the starting material. The consequently enhanced atom economy facilitates a significantly improved waste balance (E-factors down to 4), cost efficiency, and scalability (>50 g). Furthermore, the current procedure is distinguished by high levels of functional-group compatibility and stereoselectivity, as only weakly acidic cyanuric acid is released as exclusive byproduct. Finally, a one-pot protocol for the preparation of amines, azides, ethers, and sulfides enabled the synthesis of the drug rivastigmine with twofold SN2 inversion, which demonstrates the high practical value of the presented method.

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