1120364-53-5

Usage

Uses

Used in Polymer Synthesis:
2-azidoethyl 2-bromo-2-methylpropanoate is used as a bifunctional initiator for atom transfer radical polymerization (ATRP). Its bromoisobutyryl moiety plays a crucial role in initiating the polymerization process, allowing for the controlled growth of polymer chains and the synthesis of polymers with specific properties.
Used in Biomaterials:
2-azidoethyl 2-bromo-2-methylpropanoate is used as a building block in the development of biomaterials. Its azide moiety can be employed in Cu-mediated ligation, also known as "click" chemistry, which enables the efficient and selective formation of new chemical bonds. This property is particularly useful in the creation of complex biomaterials with tailored properties and functions.
Used in Carbon Nanotubes and Graphene Sheets:
2-azidoethyl 2-bromo-2-methylpropanoate is used as a functionalizing agent for carbon nanotubes and graphene sheets. The azide moiety can be utilized in "click" chemistry to attach various molecules or structures to the surface of these materials, enhancing their properties and expanding their potential applications in fields such as electronics, energy storage, and sensing.

Upstream product

• 2052-01-9 2-bromo-2-methylpropionic acid 
• 1517-05-1 2-azidoethanol 
• 20769-85-1 2-bromoisobutyric acid bromide 

Relevant academic research and scientific papers

Water-soluble dendritic-linear triblock copolymer-modified magnetic nanoparticles: Preparation, characterization and drug release properties

One route has been employed to prepare dendritic-linear block copolymer modified superparamagnetic iron oxide nanoparticles (SPIONs), which consist of a Fe3O4 magnetic nanoparticle core and a dendritic-linear block copolymer, the focal point polyamidoamine-type dendron-b-poly(2- dimethylaminoethyl methacrylate)-b-poly(N-isopropylacrylamide) (PAMAM-b-PDMAEMA-b-PNIPAM) shell by two-step atom transfer radical polymerization (ATRP). Firstly, Fe3O4 nanoparticles were prepared by a high-temperature solution phase reaction in the presence of iron(iii) acetylacetonate [Fe(acac)3], oleic acid and oleylamine. Then propargyl focal point PAMAM-type dendron (generation 2.0, denoted as propargyl-D2.0) with four carboxyl acid end groups as a cap displaced the oleic acid and oleylamine on the surfaces. Subsequently, an initiator for ATRP was introduced onto the propargyl-D2.0-modified Fe 3O4 nanoparticle surfaces via click chemistry with 2′-azidoethyl-2-bromoisobutylate (AEBIB). PDMAEMA and PNIPAM were grown gradually from nanoparticle surfaces using two-step copper-mediated ATRP. Finally, a crosslinking reaction between PDMAEMA block with 1,2-bis(2- iodoethoxy)ethane (BIEE) was used to stabilize the nanoparticles and reverse aggregation. The modified nanoparticles were subjected to detailed characterization using FT-IR, DLS, XRD and TGA. Magnetization measurements confirmed the characteristic superparamagnetic behavior of all magnetic nanoparticles under room temperature. In addition, doxorubicin (DOX) as an anticancer drug model was loaded into the dendritic-linear block copolymer shell of the modified nanoparticles, and subsequently the drug release was performed in phosphoric acid buffer solution (pH 7.4) at 25 °C or 37 °C. The results verify that dendritic-linear block copolymer-modified nanoparticles as a drug carrier possess thermosensitive drug release behaviors. Furthermore, a methyl tetrazolium (MTT) assay of DOX-loaded dendritic-linear block copolymer-modified nanoparticles against Hela cells was evaluated. The results show that the modified nanoparticles can be used for drug delivery.

Combined atom-transfer radical polymerization and ring-opening polymerization to design polymer-polypeptide copolymer conjugates toward self-aggregated hybrid micro/nanospheres for dye encapsulation

A designed orthogonal dual initiator is employed to construct poly(methyl methacrylate)-block-polytyrosine copolymer conjugates via the combination of atom-transfer radical polymerization of methyl methacrylate, "click" chemistry and ring-opening polymerization of tyrosine-α-amino acid N-carboxyanhydride monomer. The polymer-polypeptide conjugate undergoes self-aggregation in dimethylformamide to produce hybrid micro/nanospheres owing to the formation of composite micelle as evidenced from field emission scanning electron microscopy and dynamic light scattering study. A simple solution-based approach is described to encapsulate an organic dye (Rhodamine-6G) into the aggregated hybrid micro/nanospheres.

DNA-functionalized thermoresponsive bioconjugates synthesized via ATRP and click chemistry

Diblock and miktoarm star-shaped thermoresponsive copolymers composed of single-stranded DNA (ssDNA) and poly(N-isopropylacrylamide) were successfully synthesized with combination of atom transfer radical polymerization (ATRP) and click chemistry. This approach should be generalizable to other DNA-functionalized copolymers. Such copolymers self-assemble into spherical micelles with ssDNA corona in aqueous solution above the lower critical solution temperature. The micellar size can be tuned from the macromolecular architecture. These DNA-encoded micellar particles are able to encapsulate and release hydrophobic guest molecules upon changing temperature.

Process for producing chemically functionalized nano graphene materials

Provided in this invention is a process for producing chemically functionalized nano graphene materials, known as nano graphene platelets (NGPs), graphene nano sheets, or graphene nano ribbons. Subsequently, a polymer can be grafted to a functional group of the resulting functionalized graphene. In one preferred embodiment, the process comprises a step of mixing a starting nano graphene material having edges and two primary graphene surfaces, an azide or bi-radical compound, and an organic solvent in a reactor, and allowing a chemical reaction between the nano graphene material and the azide compound to proceed at a temperature for a length of time sufficient to produce the functionalized nano graphene material.

Click chemistry as a route for the immobilization of well-defined polystyrene onto graphene sheets

A facile methodology has been developed to immobilize well-defined polymers onto graphene sheets using "click" chemistry; upon polystyrene coupling, the resulting sheets can be well dispersed and fully exfoliated in common organic media. The Royal Society of Chemistry 2010.

Dendritic and linear macromolecular architectures for photovoltaics: A photoinduced charge transfer investigation

Dendrimers have been previously shown to provide significant advantages in both excited-state energy transfer and charge transfer. However, thisarchitecture causes one of the charges to be encapsulated and thus not available for charge separation over long distances. We conceived dendro n-rod-coils as scaffolds that could have the architectural advantage of the dendrimers, while still providing a possible conduit for charge separation. In this study, we have designed and synthesized dendron-rod-coil-based donor-chromophore-acceptor triads and have compared these with dendron-rod and rod-coil diads. We have then evaluated the relative abilities of these molecules in photoinduced charge transfer. Our studies reveal that dendron-rod-coil could indeed be the ideal architecture for efficient photoinduced charge separation.