7205-62-1

Upstream product

• 106-46-7 para-dichlorobenzene 
• 20607-43-6 sodium isopropanethiolate 
• 1142-19-4 4,4'-dichlorodiphenyl disulfide 
• 75-26-3 isopropyl bromide 
• 75-30-9 2-iodo-propane 
• 18803-44-6 sodium p-chlorothiophenolate 
• 106-54-7 p-Chlorothiophenol 
• 75-33-2 2-propanethiol 
• 52943-93-8 (E)-2-<(4-Chlorphenylthio)methylen>-6,6-dimethylcyclohexanon 

Downstream Products

• 87136-96-7 p-(isopropylthio)phenyl isopropyl selenide 
• 70398-91-3 4-(Methylthio)-phenyl isopropyl sulphide 
• 70398-92-4 4-(Ethylthio)-phenyl isopropyl sulphide 
• 70398-93-5 p-(Isopropylthio)-phenyl-t-butylsulfid 
• 70398-94-6 p-(Isopropylthio)-phenylsulfid 
• 52377-68-1 ethyl 2-(p-chlorophenylthio)acetate 
• 70399-08-5 1-Benzenesulfonyl-4-(propane-2-sulfonyl)-benzene 
• 70399-07-4 1-(2-Methyl-propane-2-sulfonyl)-4-(propane-2-sulfonyl)-benzene 
• 70399-06-3 1-Ethanesulfonyl-4-(propane-2-sulfonyl)-benzene 
• 70399-05-2 1-Methanesulfonyl-4-(propane-2-sulfonyl)-benzene 
• 55698-07-2 1-Chloro-4-(2-chloro-propane-2-sulfinyl)-benzene 
• 83500-75-8 1-(ethylthio)-4-(methylthio)benzene 
• 82961-63-5 4-Ethoxyphenyl isopropyl sulphone 
• 82961-62-4 4-Ethoxyphenyl ethyl sulphone 

Relevant academic research and scientific papers

Sulfonium ylide formation and subsequent C[sbnd]S bond cleavage of aromatic isopropyl sulfide catalyzed by hemin in aqueous solvent

Heme is an abundant and widely existed cofactor for a variety of metalloenzymes, whose broader use is generally impeded by its high instability and poor solubility. Here we report an environment-benign and efficient strategy for the sulfonium ylide formation and subsequent C[sbnd]S bond cleavage of aromatic isopropyl sulfides, which was catalyzed by hemin in assistance of Triton X-100. This aqueous catalytic system exhibited good functional group tolerance to a variety of sulfides and diazo esters. And the reaction mechanism was preliminarily proposed on the basis of designed reactions. Furthermore, the cleavage of C[sbnd]S bond followed by introducing a functional ester group to aromatic sulfides, may potentially be employed for the late stage functionalization (LSF) of organosulfur drug in the future.

Sulfite-promoted one-pot synthesis of sulfides by reaction of aryl disulfides with alkyl halides

A sodium dithionite, sodium thiosulfate and rongalite promoted one-pot synthesis of aryl alkyl sulfides at room temperature has been developed. The reactions of a range of disulfides with alkyl halides proceeded smoothly in the presence of rongalite. Possible reaction pathways are discussed and the effects of these sulfites on disulfides are investigated. The important features of this protocol are metal-free, strong-base-free, and mild reaction conditions, operational simplicity, short reaction times and high yields of products. Georg Thieme Verlag Stuttgart.

Sulfonyl benzimidazole derivatives

This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein A, B, R1, R2 and R3 are each as described herein, and compositions containing such compounds, and the use of such compounds in the treatment of a condition mediated by CB2 receptor activity such as, but not limited to, inflammatory pain, nociceptive pain, neuropathic pain, fibromyalgia, chronic low back pain, visceral pain, acute cerebral ischemia, pain, chronic pain, acute pain, post herpetic neuralgia, neuropathies, neuralgia, diabetic neuropathy, HIV-related neuropathy, nerve injury, rheumatoid arthritic pain, osteoarthritic pain, back pain, cancer pain, dental pain, fibromyalgia, neuritis, sciatica, inflammation, neurodegenerative disease, cough, broncho constriction, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), colitis, cerebrovascular ischemia, emesis such as cancer chemotherapy-induced emesis, rheumatoid arthritis, asthma, Crohn's disease, ulcerative colitis, asthma, dermatitis, seasonal allergic rhinitis, GERD, constipation, diarrhea, functional gastrointestinal disorders, irritable bowel syndrome, cutaneous T cell lymphoma, multiple sclerosis, osteoarthritis, psoriasis, systemic lupus erythematosus, diabetes, glaucoma, osteoporosis, glomerulonephritis, renal ischemia, nephritis, hepatitis, cerebral stroke, vasculitis, myocardial infarction, cerebral ischemia, reversible airway obstruction, adult respiratory disease syndrome, COPD, cryptogenic fibrosing alveolitis and bronchitis.

Synthesis of α-chloroalkyl ethers from phenols

α-Chloroalkyl aryl ethers has been obtained in good yields from phenols and aryl α-chloroalkyl sulfides.

Properties of an (Arylthiomethylene)cyclohexanone

The configuration of 2--6,6-dimethylcyclohexanone (2) and the reactions of 2--6,6-dimethylcyclohexanone (3) with electrophiles have been investigated.

SELECTIVE MONO-ARYLATION AND -ALKYLATION OF CHLOROPHENYL ALKYL SULFIDES BY NICKEL CATALYSED CROSS-COUPLING WITH GRIGNARD REAGENTS

Chlorophenyl alkyl sulfides are mono-arylated and -alkylated selectively with Grignard reagents, in the presence of Ni(PPh3)2Cl2, to give aryl- and alkyl-phenyl alkyl sulfides.

Reactions of Polychlorobenzenes with Alkanethiol Anions in HMPA. A Simple, High-Yield Synthesis of Poly(alkylthio)benzenes

Reactions of the isomeric trichlorobenzenes and tetrachlorobenzenes and of pentachloro- and hexachlorobenzene with an excess of the sodium salt of the isopropanethiol, in HMPA, afforded the products of complete displacement of all the chlorine atoms present in the molecule.Similar substitutions were also obtained with EtSNa.The reactions with MeSNa were in some cases complicated by the competitive nucleophilic attack at the methyl group of the initially formed aryl methyl thioethers which are thus demethylated to afford thiophenols.