1123172-01-9

Basic information

• Product Name: Methyl 4-amino-3-fluoro-5-iodobenzoate
• Synonyms: Methyl 4-amino-3-fluoro-5-iodobenzoate;2-Fluoro-6-iodo-4-(methoxycarbonyl)aniline;Methyl 4-amino-3-fluoro-5-iodobenzoate 95+%
• CAS NO: 1123172-01-9
• Molecular Formula: C₈H₇FINO₂
• Molecular Weight: 295
• Mol File: 1123172-01-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl 4-amino-3-fluoro-5-iodobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-amino-3-fluoro-5-iodobenzoate(1123172-01-9)
• EPA Substance Registry System: Methyl 4-amino-3-fluoro-5-iodobenzoate(1123172-01-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1123172-01-9(Hazardous Substances Data)

Usage

General Description

Methyl 4-amino-3-fluoro-5-iodobenzoate is a chemical compound with the molecular formula C8H7FINO2. It is a derivative of benzoic acid and contains a fluorine and iodine atom, as well as an amino group. Methyl 4-amino-3-fluoro-5-iodobenzoate is commonly used in organic synthesis and medicinal chemistry, particularly in the development of pharmaceuticals. It has been studied for its potential therapeutic applications, including as an antifungal and antibacterial agent. Methyl 4-amino-3-fluoro-5-iodobenzoate is also used as a building block in the synthesis of various complex organic molecules.

Upstream product

• 455-87-8 4-amino-3-fluorobenzoic acid 
• 185629-32-7 methyl 4-amino-3-fluorobenzene carboxylate 

Downstream Products

• 1123172-02-0 4-amino-3-but-1-ynyl-5-fluoro-benzoic acid methyl ester 
• 849353-46-4 4-amino-3-fluoro-5-iodo-benzonitrile 

Relevant articles and documents

Preparation method of Tropifexor

The invention discloses a method for preparing a compound as shown in a formula (I). The method comprises the step of reacting a compound as shown in a formula (II), a compound as shown in a formula (III) and carbon disulfide in an organic solvent, wherein in the formula (I), R1 is H, D, OCF3, OCHF2, CF3, F, Cl, Br, C1-6 alkyl and C1-6 alkoxy; R2 is H, D, F, Cl, Br, a C1-6 alkyl group or a C1-6 alkoxy group; and R3 is H or C1-6 alkyl. The method has the advantages of short steps, cheap raw materials, mild conditions, high total yield and small influence on operators and environment, and is especially suitable for industrial production.

NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS

The present invention discloses compounds according to Formula (I), wherein R1, R3, R4, R5, L1, and Cy are as defined herein. The present invention also provides compounds, methods for the production of said compounds of the invention, pharmaceutical compositions comprising the same and their use in allergic or inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 and/or interferons. The present invention also methods for the prevention and/or treatment of the aforementioned diseases by administering a compound of the invention.