112375-54-9

Upstream product

• 179617-42-6 2-((E)-6-Methyl-hept-4-enyl)-malonic acid dimethyl ester 
• 502-44-3 hexahydro-2H-oxepin-2-one 
• 6654-36-0 methyl 6-oxohexanoate 
• 4547-43-7 methyl 6-hydroxycaproate 
• 67-56-1 methanol 
• 404-86-4 capsaicin 
• 179617-47-1 trans-6-methyl-hept-4-enoic acid ethyl ester 
• 179617-41-5 Methanesulfonic acid (E)-6-methyl-hept-4-enyl ester 
• 59721-82-3 (E)-1-hydroxy-6-methylhept-4-ene 

Downstream Products

• 59320-77-3 trans-8-methyl-6-nonenoic acid 
• 205687-01-0 capsiate 
• 946572-73-2 coniferyl (E)-8-methyl-6-nonenoate 
• 19408-84-5 dihydrocapsaicin 
• 71226-60-3 Bishomocapsaicin 
• 58493-48-4 trans-9-methyl-N-vanillyl-7-decenamide 
• 95636-02-5 (E)-8-Methylnon-6-enoic acid chloride 
• 404-86-4 capsaicin 

Relevant academic research and scientific papers

Isolation of coniferyl esters from Capsicum baccatum L., and their enzymatic preparation and agonist activity for TRPV1

Coniferyl esters-capsiconiate and dihydrocapsiconiate-were isolated from the fruits of the pepper, Capsicum baccatum L. var. praetermissum. Their structures were determined by spectroscopic methods to be coniferyl (E)-8-methyl-6-nonenoate (capsiconiate) a

Topically applied circulation enhancing agent and skin and hair cosmetic and bath agent containing the same

A topically applied circulation enhancing agent suited for application over the entire body which has good transdermal absorptivity and causes little irritation is provided. A topically applied circulation enhancing agent is provided which contains a fatty acid ester denoted by general formula (1):

A general and stereoselective synthesis of the capsaicinoids via the orthoester Claisen rearrangement

Capsaicin, a main pungent principle of hot pepper, and its 15 analogs have been efficiently synthesized. The key step of this synthetic scheme is the orthoester Claisen rearrangement, which transformed allylic alcohols 2A-C to (E)-alkenoates 3A-C (E/Z > 100) in a highly stereoselective manner. The subsequent carbon chain elongations on 3 based on the cyanation or the malonic acid ester synthesis afforded (E)-alkenoic acids 8, which were converted to the corresponding acid chloride and then coupled with vanillylamine to give capsaicinoids. HPLC and CE (capillary electrophoresis) analyses of these capsaicinoids were also carried out.

The Capsaicinoids: Their Separation, Synthesis, and Mutagenicity

Capsaicin (1b), the pungent ingredient in many varietes of Capsicums has recently been implicated as a possible carcinogen.When obtained from natural sources 1b is always accompanied by a number of related homologues.We have isolated seven of these homologues, characterized them, and synthesized them by a general and unique route developed in our laboratories.Also reported are mutagenicity data for 1b and an extract of red pepper as measured by the Ames assay and the V-79 mammalian cell assay.