1123785-74-9

Upstream product

• 1123785-11-4 (2R,3R,6S)-7-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-2,6-dimethylheptan-1-ol 
• 180692-68-6 (S)-5-(phenylmethoxy)-4-methylpentanal 
• 391208-05-2 (S)-1-((2-methylpent-4-enyloxy)methyl)benzene 
• 100-39-0 benzyl bromide 
• 887706-39-0 (S)-5-(benzyloxy)-4-methylpentan-1-ol 
• 943856-58-4 (S)-4-benzyl-3-((S)-2-methylpent-4-enoyl)oxazolidin-2-one 

Downstream Products

• 1123785-45-4 (4R,5R)-4-((S)-4-(benzyloxy)-3-methylbutyl)-2,2,5-trimethyl-1,3-dioxane 

Relevant academic research and scientific papers

Highly stereoselective approach toward the synthesis of the macrolactone core of amphidinolide W

The diastereoselective synthesis of the macrolactone core of amphidinolide W was successfully accomplished using Evans' asymmetric alkylation, Aldol reaction, Julia-Kocienski olefination, and Kita's macrocyclization protocol.

Asymmetric synthesis of a 12-membered macrolactone core and a 6-epi analogue of amphidinolide W from 4-pentenoic acid

A flexible and efficient asymmetric route to the synthesis of a 12-membered macrolactone core and a 6-epi analogue of amphidinolide W has been accomplished from commercially available 4-pentenoic acid. The successful generation of stereocenters was achieved by utilizing an Evans' chiral auxiliary-based alkylation and aldol reaction. Other key reactions such as a Julia-Kocienski olefination, Kita's macrolactonization, ring closing metathesis (RCM) reaction, and Yamaguchi's esterification were significant for the construction of the macrolactone cores.