1125632-11-2Relevant articles and documents
Rapid Access to Orthogonally Functionalized Naphthalenes: Application to the Total Synthesis of the Anticancer Agent Chartarin
Unzner, Teresa A.,Grossmann, Adriana S.,Magauer, Thomas
, p. 9763 - 9767 (2016)
We report the synthesis of orthogonally functionalized naphthalenes from simple, commercially available indanones in four steps. The developed method proceeds through a two-step process that features a thermally induced fragmentation of a cyclopropane indanone with simultaneous 1,2-chloride shift. Migration of the chloride substituent occurs in a regioselective manner to preferentially afford the para-chloronaphthol substitution pattern. The obtained naphthols are versatile building blocks that can be selectively modified and used for the efficient construction of biologically active molecules. This has enabled the total synthesis of the potent anticancer natural product chartarin through a highly convergent retrosynthetic bond disconnection.
GLUCOSE UPTAKE INHIBITORS
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Paragraph 0818; 0820-0822, (2020/01/24)
this invention provides compounds that modulate glucose uptake activity and cellular transport/uptake of glucose, and particularly GLUTS3, but also including but not limited to GLUT1-14 (SLC2A1-SLC2A14). Compounds of the invention are useful for treating diseases, including cancer, autoimmune diseases and inflammation, infectious diseases, and metabolic diseases.
CHEMILUMINESCENT PROBES FOR DIAGNOSTICS AND IN VIVO IMAGING
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Paragraph 00133; 00134, (2017/08/24)
The present invention provides dioxetane-based chemiluminescence probes, more specifically ?uorophore-tethered dioxetane-based chemiluminescence probes and π* acceptor group-containing dioxetane based chemiluminescence probes, and compositions thereof. Th