1125632-11-2

Usage

Uses

Used in Cosmetic and Personal Care Products:
Methyl 2-chloro-3-hydroxybenzoate is used as a preservative for its antimicrobial properties, which help prevent the growth of bacteria and fungi, ensuring the safety and longevity of cosmetic and personal care products.
Used in Food and Beverages:
In the food and beverage industry, Methyl 2-chloro-3-hydroxybenzoate is used as a preservative to maintain the freshness and quality of products by inhibiting microbial growth, thus extending their shelf life.
Used in Pharmaceuticals and Medical Products:
Methyl 2-chloro-3-hydroxybenzoate is utilized as an ingredient in pharmaceuticals and medical products to extend their shelf life and maintain product quality, leveraging its antimicrobial properties to prevent contamination and degradation.

Upstream product

• 67-56-1 methanol 
• 51786-10-8 2-Chloro-3-hydroxy benzoic acid 
• 19438-10-9 methyl 3-hydroxybenzoate 
• 56962-10-8 2-chloro-3-hydroxybenzaldehyde 

Downstream Products

• 1207343-93-8 4-bromo-2-chloro-3-hydroxybenzoic acid methyl ester 
• 59425-26-2 2-Chloro-3-methoxybenzoic acid methyl ester 

Relevant academic research and scientific papers

Rapid Access to Orthogonally Functionalized Naphthalenes: Application to the Total Synthesis of the Anticancer Agent Chartarin

We report the synthesis of orthogonally functionalized naphthalenes from simple, commercially available indanones in four steps. The developed method proceeds through a two-step process that features a thermally induced fragmentation of a cyclopropane indanone with simultaneous 1,2-chloride shift. Migration of the chloride substituent occurs in a regioselective manner to preferentially afford the para-chloronaphthol substitution pattern. The obtained naphthols are versatile building blocks that can be selectively modified and used for the efficient construction of biologically active molecules. This has enabled the total synthesis of the potent anticancer natural product chartarin through a highly convergent retrosynthetic bond disconnection.

GLUCOSE UPTAKE INHIBITORS

this invention provides compounds that modulate glucose uptake activity and cellular transport/uptake of glucose, and particularly GLUTS3, but also including but not limited to GLUT1-14 (SLC2A1-SLC2A14). Compounds of the invention are useful for treating diseases, including cancer, autoimmune diseases and inflammation, infectious diseases, and metabolic diseases.

Ammonium Salt-Catalyzed Highly Practical Ortho-Selective Monohalogenation and Phenylselenation of Phenols: Scope and Applications

An ortho-selective ammonium chloride salt-catalyzed direct C-H monohalogenation of phenols and 1,1′-bi-2-naphthol (BINOL) with 1,3-dichloro-5,5-dimethylhydantoin (DCDMH) as the chlorinating agent has been developed. The catalyst loading was low (down to 0.01 mol %) and the reaction conditions were very mild. A wide range of substrates including BINOLs were compatible with this catalytic protocol. Chlorinated BINOLs are useful synthons for the synthesis of a wide range of unsymmetrical 3-aryl BINOLs that are not easily accessible. In addition, the same catalytic system can facilitate the ortho-selective selenylation of phenols.

CHEMILUMINESCENT PROBES FOR DIAGNOSTICS AND IN VIVO IMAGING

The present invention provides dioxetane-based chemiluminescence probes, more specifically ?uorophore-tethered dioxetane-based chemiluminescence probes and π* acceptor group-containing dioxetane based chemiluminescence probes, and compositions thereof. Th

The Catalyst-Controlled Regiodivergent Chlorination of Phenols

Different catalysts are demonstrated to overcome or augment a substrate's innate regioselectivity. Nagasawa's bis-thiourea catalyst was found to overcome the innate para-selectivity of electrophilic phenol chlorination, yielding ortho-chlorinated phenols that are not readily obtainable via canonical electrophilic chlorinations. Conversely, a phosphine sulfide derived from 2,2′-Bis(diphenylphosphino)-1,1′-binaphthyl (BINAP) was found to enhance the innate para-preference of phenol chlorination.