112572-49-3

Upstream product

• 4179-00-4 Methyl (E)-3-methyl-5-(2,6,6-trimethylcyclohexen-1-yl)-2-pentenoate 
• 18665-81-1 (E)-3-methyl-5-(2',6',6'-trimethylcyclohex-1'-en-1'-yl)pent-2-en-1-ol 
• 29550-53-6 (E)-3-methyl-5-(2',6',6'-trimethylcyclohex-1'-enyl)pent-2-enyl bromide 
• 158322-10-2 (E)-1-<(tert-butyl)dimethylsiloxy>-6-methyl-8-(2',6',6'-trimethylcyclohex-1'-enyl)oct-5-en-2-one 
• 158322-09-9 N'-[(E)-1-(tert-Butyl-dimethyl-silanyloxymethyl)-5-methyl-7-(2,6,6-trimethyl-cyclohex-1-enyl)-hept-4-en-(E)-ylidene]-N,N-dimethyl-hydrazine 
• 117155-25-6 4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-[(2E,6E)-3-(tert-butyl-dimethyl-silanyloxymethyl)-7-methyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,6-dienyl]-5-hydroxy-5H-furan-2-one 
• 112503-53-4 3-(tert-Butyl-dimethyl-silanyloxymethyl)-2-[(2E,6E)-3-(tert-butyl-dimethyl-silanyloxymethyl)-7-methyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,6-dienyl]-5-trimethylsilanyl-furan 
• 117155-23-4 {2-[(2Z,6E)-3-Dimethoxymethyl-7-methyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,6-dienyl]-5-trimethylsilanyl-furan-3-yl}-methanol 
• 112503-55-6 (E)-2-[2-(3-Hydroxymethyl-5-trimethylsilanyl-furan-2-yl)-eth-(E)-ylidene]-6-methyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-oct-5-en-1-ol 
• 112503-52-3 (E)-2-[2-(3-Hydroxymethyl-5-trimethylsilanyl-furan-2-yl)-eth-(E)-ylidene]-6-methyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-oct-5-enal 
• 112503-51-2 2-trimethylsilyl-4-hydroxymethyl-5-tributyl-stannylfuran 
• 112503-50-1 2-((3E,7Z)-9-Chloro-7-dimethoxymethyl-3-methyl-nona-3,7-dienyl)-1,3,3-trimethyl-cyclohexene 
• 158044-94-1 2-<(tert-butyl)dimethylsiloxy>-4-<<(tert-butyl)dimethylsiloxy>methyl>furan 
• 80904-75-2 4-hydroxymethyl-5H-furan-2-one 

Downstream Products

• 80433-17-6 Acetic acid (E)-2-[2-(3-acetoxymethyl-5-oxo-2,5-dihydro-furan-2-yl)-eth-(Z)-ylidene]-6-methyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-oct-5-enyl ester 
• 105498-76-8 seco-manoalide 
• 80433-16-5 (E)-2-[2-(3-Hydroxymethyl-5-oxo-2,5-dihydro-furan-2-yl)-eth-(Z)-ylidene]-6-methyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-oct-5-enal 

Relevant academic research and scientific papers

A concise synthesis of (E)- and (Z)-neomanoalides

The first synthesis of (Z)-neomanoalide (4) and an improved synthesis of its (E)-isomer 3 was accomplished in a concise, regiocontrolled manner by exploiting 2-[(tert-butyl)dimethylsiloxy]-4{[(tert-butyl)dimethylsiloxy]methyl} furan (6) as the key reagent

TOTAL SYNTHESIS OF E-NEOMANOALIDE VIA Pd(O) CATALYZED COUPLING OF ALLYLHALIDE AND &α-STANNYLFURAN FOLLOWED BY CHEMOSELECTIVE OXYGENATION OF &α-SILYLFURAN

The first synthesis of E-neomanoalide (1) from an allylchloride 3 was achieved in short steps by Pd(O) catalyzed coupling with a α-stannylfuran derivative 5 followed by chemoselective oxygenation of a α-silylfuran derivative 2 and reduction.The essential