112607-05-3

Upstream product

• 36978-49-1 4-(4-chlorobenzoyl)butanoic acid 
• 40297-26-5 (±)-2-(4-chlorophenyl)cyclopentan-1-one 
• 108-55-4 glutaric anhydride, 
• 108-90-7 chlorobenzene 
• 161725-12-8 5-(4-chlorophenyl)pentanoic acid 

Downstream Products

• 116691-49-7 6-(4-chlorophenyl)-1-phenyl-2-piperidone 

Relevant academic research and scientific papers

145. Analytic and Preparative Resolution on Racemic γ- and δ-Lactones by Chromatography on Cellulose Triacetate. Relationship between Elution Order and Absolute Configuration

Enantiomers of various chiral five- and six-membered-ring lactones, which are important classes of cpmpounds (flavour and pheromone components, key intermediates in the synthesis of biologically active substrates) have been separated chromatographically on the chiral phase cellulose triacetate, crystallographic form I (CTA I).Four different series of five-membered-ring lactones, relationships have been found between the elution order of the enantiomers and their absolute configuration.Preparative resolutions of γ-phenyl-γ-butyrolactone (1) and of the pheromone component 5b have been carried out to demonstrate the applicability of the method to g-scale separations.

Controlling Chemoselectivity of Catalytic Hydroboration with Light

The ability to selectively react one functional group in the presence of another underpins efficient reaction sequences. Despite many designer catalytic systems being reported for hydroboration reactions, which allow introduction of a functional handle fo

Synthesis method of 6-(4-((2-cyclohexylthioethyl)amino)phenyl)tetrahydro-2H-pyran-2-one

The invention discloses a synthesis method and application of 6-(4-((2-cyclohexylthioethyl)amino)phenyl)tetrahydro-2H-pyran-2-one, and relates to the technical field of essence synthesis. A compound 1is prepared, and is a novel compound, and it is found that the compound has unique costustoot aroma, and the aroma is light sweet, pure, soft, good in aroma diffusivity and long in aroma retention time; meanwhile, the purity of the compound 1 reaches 99% or above, so that the essence blending requirement is met; and in addition, the compound 1 is also added into a PVC floor, so that the PVC flooremits fragrance similar to that of a solid wood floor, the use quality of the PVC floor is improved, and the problem of natural resource consumption caused by use of the solid wood floor is avoided.

Cooperative iodine and photoredox catalysis for direct oxidative lactonization of carboxylic acids

A new method for the formation of γ- and δ-lactones from carboxylic acids through direct conversion of benzylic C-H to C-O bonds is described. The reaction is conveniently induced by visible light and relies on a mild cooperative catalysis by the combination of molecular iodine and an organic dye.

NEW CCR2 RECEPTOR ANTAGONISTS AND USES THEREOF

The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD.

Lactam derivatives

There is disclosed a lactam derivative of the formula: STR1 wherein R1 is a substituted or unsubstituted phenyl group; R2 is a substituted or unsubstituted phenyl group, a cycloalkyl group or a nitrogen-containing 6-membered heterocy