1126635-20-8

Basic information

• Product Name: IMidazo[1,2-a]pyridine, 6-fluoro-2-phenyl-
• Synonyms: IMidazo[1,2-a]pyridine, 6-fluoro-2-phenyl-;6-Fluoro-2-phenylimidazo[1,2-a]pyridine
• CAS NO: 1126635-20-8
• Molecular Formula: C13H9FN2
• Molecular Weight: 212.2223632
• Mol File: 1126635-20-8.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: IMidazo[1,2-a]pyridine, 6-fluoro-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: IMidazo[1,2-a]pyridine, 6-fluoro-2-phenyl-(1126635-20-8)
• EPA Substance Registry System: IMidazo[1,2-a]pyridine, 6-fluoro-2-phenyl-(1126635-20-8)

Safety Data

• Hazardous Substances Data: 1126635-20-8(Hazardous Substances Data)

Usage

General Description

Imidazo[1,2-a]pyridine, 6-fluoro-2-phenyl- is a chemical compound that belongs to the class of heterocyclic compounds. It is characterized by its imidazo ring fused with a pyridine ring, with a fluorine atom at position 6 and a phenyl group attached to position 2. This chemical structure makes it useful in pharmaceutical research and drug development, as it can exhibit a wide range of biological activities. It can be used as a building block in the synthesis of various pharmaceuticals and bioactive compounds with potential therapeutic applications. Additionally, it may also be utilized in research studies related to its structure-activity relationship and pharmacological properties.

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Relevant articles and documents

PhI(OAc)2-mediated oxidative C[sbnd]H sulfoximination of imidazopyridines under mild conditions

A facile protocol for direct oxidative C[sbnd]N bond coupling of unactivated imidazo[1,2-a]pyridines with NH-sulfoximines was disclosed using sulfoximines as the nitrogen sources in the presence of (diacetoxy)iodobenzene (PhI(OAc)2). The reacti

Design, synthesis, and biological evaluation of fluorinated imidazo[1,2-a]pyridine derivatives with potential antipsychotic activity

Based on our recent finding that α1selective GABA-A receptor potentiator—zolpidem—(a hypnotic drug) exerts antipsychotic-like effects in rats, we developed a series of fluorinated imidazo[1,2-a]pyridine derivatives as potential novel antipsychotic agents. The selected compounds displayed high affinity and positive allosteric modulator properties at the GABA-A receptor, enhanced metabolic stability and lack of hepatotoxicity. The most promising compound 2-(2-(4-fluorophenyl)-6-methylimidazo[1,2-a]pyridin-3-yl)-N,N-dimethylethanamide (26) showed antipsychotic-like activity in amphetamine-induced hyperlocomotion test in rats (MED = 1 mg/kg) and was characterized by a longer duration of antipsychotic-like activity as compared to zolpidem. These results are an encouraging example of a compound with non-dopaminergic mechanism of action displaying antipsychotic activity and are a point of entry for the future studies in this field.

One-pot NBS-promoted synthesis of imidazoles and thiazoles from ethylarenes in water

A facile and eco-friendly method has been developed for the synthesis of imidazoles and thiazoles from ethylarenes in water. The reaction proceeds via in situ formation of α-bromoketone using NBS as a bromine source as well as an oxidant, followed by trapping with suitable nucleophiles to provide the corresponding products in good yields under metal-free conditions.

Electrochemical Oxidative C—H Sulfenylation of Imidazopyridines with Hydrogen Evolution

Selective oxidative C—H sulfenylation of imidazopyridine heterocycles is achieved using an undivided electrolytic cell. The reaction avoids the use of stoichiometric amount of external chemical oxidant and produces hydrogen gas as the only byproduct. Both