228574-31-0

Basic information

• Product Name: 5,8-Isoquinolinedione, 6-chloro-7-[[4-(2-hydroxyethyl)phenyl]amino]-
• CAS NO: 228574-31-0
• Molecular Formula: C17H13ClN2O3
• Molecular Weight: 328.755
• Mol File: 228574-31-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5,8-Isoquinolinedione, 6-chloro-7-[[4-(2-hydroxyethyl)phenyl]amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 5,8-Isoquinolinedione, 6-chloro-7-[[4-(2-hydroxyethyl)phenyl]amino]-(228574-31-0)
• EPA Substance Registry System: 5,8-Isoquinolinedione, 6-chloro-7-[[4-(2-hydroxyethyl)phenyl]amino]-(228574-31-0)

Safety Data

• Hazardous Substances Data: 228574-31-0(Hazardous Substances Data)

Upstream product

• 156901-61-0 8-amino-5-nitro-isoquinoline 
• 1127-49-7 5,8-diaminoisoquinoline 
• 84289-03-2 DA 295 
• 104-10-9 2-(4'-aminophenyl)ethyl alcohol 
• 607-32-9 5-nitroisoquinoline 

Relevant articles and documents

Synthesis and cytotoxic activities of 6-chloro-7-arylamino-5,8- isoquinolinediones

6-Chloro-7-arylamino-5,8-isoquinolinediones were newly synthesized and evaluated for in vitro cytotoxic activities against five human solid tumor cell lines. Among them, 5b, 5c and 5d exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.

7-(Substituted-phenyl)amino-5,8-isoquinolinediones: Synthesis and cytotoxic activities on cancer cell lines

6-Chloro-7-(substituted-phenyl)amino-5,8-isoquinolinediones (3a-3u) and 7-(substituted-phenyl)amino-5,8-isoquinolinediones (4a-4d) were synthesized by nucleophilic substitution of 6,7-dichloro-5,8-isoquinolinedione (8) and 5,8-isoquinolinedione (9) with appropriate arylamines. The quinones 3a-3u and 4a-4d were evaluated for in vitro cytotoxic activities against five solid tumor cell lines such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT-15. Among them, 3c, 3d, 3f and 3h exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.