228574-31-0Relevant academic research and scientific papers
Synthesis and cytotoxic activities of 6-chloro-7-arylamino-5,8- isoquinolinediones
Ryu, Chung-Kyu,Lee, In-Kyung,Jung, Sung-Hee,Lee, Chong-Ock
, p. 1075 - 1080 (1999)
6-Chloro-7-arylamino-5,8-isoquinolinediones were newly synthesized and evaluated for in vitro cytotoxic activities against five human solid tumor cell lines. Among them, 5b, 5c and 5d exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.
Synthesis of 6-chloroisoquinoline-5,8-diones and pyrido[3,4-b]phenazine-5,12-diones and evaluation of their cytotoxicity and DNA topoisomerase II inhibitory activity
Kim, Jin Sung,Rhee, Hee-Kyung,Park, Hyen Joo,Lee, In-Kyoung,Lee, Sang Kook,Suh, Myung-Eun,Lee, Hwa Jeong,Ryu, Chung-Kyu,Choo, Hea-Young Park
, p. 451 - 457 (2008/02/10)
The substituted chloroisoquinolinediones and pyrido[3,4-b]phenazinediones were synthesized, and the cytotoxic activity and topoisomerase II inhibitory activity of the prepared compounds were evaluated. Chloroisoquinolinediones have been prepared by the re
7-(Substituted-phenyl)amino-5,8-isoquinolinediones: Synthesis and cytotoxic activities on cancer cell lines
Ryu, Chung-Kyu,Lee, In-Kyung,Jung, Sung-Hee,Kang, Hye-Young,Lee, Chong-Ock
, p. 40 - 49 (2007/10/03)
6-Chloro-7-(substituted-phenyl)amino-5,8-isoquinolinediones (3a-3u) and 7-(substituted-phenyl)amino-5,8-isoquinolinediones (4a-4d) were synthesized by nucleophilic substitution of 6,7-dichloro-5,8-isoquinolinedione (8) and 5,8-isoquinolinedione (9) with appropriate arylamines. The quinones 3a-3u and 4a-4d were evaluated for in vitro cytotoxic activities against five solid tumor cell lines such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT-15. Among them, 3c, 3d, 3f and 3h exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.
