296776-08-4Relevant academic research and scientific papers
Synthesis of 6-chloroisoquinoline-5,8-diones and pyrido[3,4-b]phenazine-5,12-diones and evaluation of their cytotoxicity and DNA topoisomerase II inhibitory activity
Kim, Jin Sung,Rhee, Hee-Kyung,Park, Hyen Joo,Lee, In-Kyoung,Lee, Sang Kook,Suh, Myung-Eun,Lee, Hwa Jeong,Ryu, Chung-Kyu,Choo, Hea-Young Park
, p. 451 - 457 (2008/02/10)
The substituted chloroisoquinolinediones and pyrido[3,4-b]phenazinediones were synthesized, and the cytotoxic activity and topoisomerase II inhibitory activity of the prepared compounds were evaluated. Chloroisoquinolinediones have been prepared by the re
7-(Substituted-phenyl)amino-5,8-isoquinolinediones: Synthesis and cytotoxic activities on cancer cell lines
Ryu, Chung-Kyu,Lee, In-Kyung,Jung, Sung-Hee,Kang, Hye-Young,Lee, Chong-Ock
, p. 40 - 49 (2007/10/03)
6-Chloro-7-(substituted-phenyl)amino-5,8-isoquinolinediones (3a-3u) and 7-(substituted-phenyl)amino-5,8-isoquinolinediones (4a-4d) were synthesized by nucleophilic substitution of 6,7-dichloro-5,8-isoquinolinedione (8) and 5,8-isoquinolinedione (9) with appropriate arylamines. The quinones 3a-3u and 4a-4d were evaluated for in vitro cytotoxic activities against five solid tumor cell lines such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT-15. Among them, 3c, 3d, 3f and 3h exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.
