1127-93-1

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Diaminopteridine is used as a chemical intermediate for the synthesis of various pharmaceuticals, leveraging its unique chemical properties to facilitate the creation of new and effective medications.
Used in Dye Industry:
In the dye industry, 2,4-Diaminopteridine is utilized as a key component in the production of dyes, capitalizing on its ability to contribute to the color and stability of these products.
Used in Vitamin Production:
2,4-Diaminopteridine is used as a precursor in the production of folic acid, an essential vitamin crucial for various bodily functions, including DNA synthesis, cell division, and the formation of red blood cells.
Used in Drug Development:
2,4-Diaminopteridine is employed in the development of new drugs, serving as a foundation for the creation of innovative pharmaceuticals that address unmet medical needs.
Used in Biochemical Research:
2,4-Diaminopteridine is used in biochemical research to explore its potential applications and understand its interactions within biological systems, furthering scientific knowledge and potentially leading to breakthroughs in medicine.

InChI:InChI=1/C6H6N6/c7-4-3-5(10-2-1-9-3)12-6(8)11-4/h1-2H,(H4,7,8,10,11,12)

Upstream product

• 1004-74-6 2,4,5,6-tetraaminopyrimidine 
• 517-21-5 glyoxal sodium bisulfite 
• 15891-13-1 2,4-diamino-5,6,7,8-tetrahydropteridine 
• 13165-97-4 N²-acetylpterin 
• 21071-37-4 2,4,6,7-tetrachloropteridine 
• 2817-14-3 5,8-dihydro-1H-pteridine-2,4,6,7-tetraone 
• 98142-36-0 2,4-dichloro-5,6,7,8-tetrahydro-pteridine 
• 522614-23-9 4-[2-(4-nitrophenyl)ethoxy]pteridin-2-amine 
• 25911-65-3 2-amino-3-pyrazinonitrile 
• 593-85-1 diguanidine carbonate 
• 522614-07-9 N-{4-[2-(4-nitrophenyl)ethoxy]pteridin-2-yl}acetamide 
• 131543-46-9 Glyoxal 

Downstream Products

• 2236-60-4 2-aminopteridin-4(3H)-one 
• 487-21-8 Lumazine 

Relevant academic research and scientific papers

Pteridines. Part CXIII. Protection of Pteridines

The low solubulity of pterins can drastically be improved by N2-acylation or formation of the N2-[(dimethylamino)methylene] derivatives. Both types of compounds can be alkylated under Mitsunobu conditions to form from N2-acylpterins (see 2 and 3) and their derivatives (see 5, 6, 8, 9, 11, 13, 15, and 17) selectively the O4-alkyl derivatives 22-31, whereas the electron-donating [(dimethylamino)methyleneamino] function in 46-51 gives, in a selective reaction, the N(3)-substitution (->52-61). N2,N2-Dimethylpterins and 18 and 19 and N2-methylpterins 20 and 21 direct alkylation also to the O4-position (->32-35, 38 and 39). Deacylation can be achieved under very mild conditions by solvolysis with MeOH (22->40, 26->41), and displacement of the O4-[2-(4-nitrophenyl)ethyl] group proceeds with ammonia at room temperature to the corresponding pteridin-2,4-diamine 42-45. Cleavage of the N2-[(dimethylamino)methylene] group works well with ammonia (->62-67). The advantage of applying the 2-(4-nitrophenyl)ethyl (npe) group as blocking group is seen in its selective removal by 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) under aprotic conditions without harming the other substituents.

Syntheses of 1-allyl-6-(arylamino)methyl-7-methyl-3-phenylpteridine-2,4-dione, a methanopterin analogue

The nucleophilic substitution of 2,3-dicyanopyrazine (1) with allylamine is useful for the construction of pteridine ring. A methanopterin analogue, 1-allyl-6-(mesitylamino)methyl-7-methy-3-phenylpteridine (12), was synthesised by this method from 2,3-dic