112700-85-3

Upstream product

• 67-56-1 methanol 
• 70678-13-6 1,2-bis(1-isocyanato-1-methylethyl)diazene 
• 107-10-8 propylamine 
• 119493-14-0 4-Benzoyl-5,5-dimethyl-Δ¹-1,2,4-triazolin-3-one 
• 64-17-5 ethanol 
• 67-63-0 isopropyl alcohol 
• 100-46-9 benzylamine 
• 100-51-6 benzyl alcohol 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 130138-08-8 4-benzyl-4,5-dihydro-5,5-dimethyl-1,2,4-triazol-3-one 
• 119493-14-0 4-Benzoyl-5,5-dimethyl-Δ¹-1,2,4-triazolin-3-one 
• 130138-03-3 4-(chloroacetyl)-4,5-dihydro-5,5-dimethyl-1,2,4-triazol-3-one 
• 130138-04-4 4,5-dihydro-5,5-dimethyl-4-(4-methylbenzenesulfonyl)-1,2,4-triazol-3-one 
• 119493-09-3 4-Aminocarbonyl-5,5-dimethyl-Δ¹-1,2,4-triazolin-3-one 
• 161957-99-9 4,5-dihydro-5,5-dimethyl-3-oxo-3H-1,2,4-triazole-1-oxide 
• 130138-06-6 4,5-dihydro-5,5-dimethyl-4-phenylcarbamoyl-1,2,4-triazol-3-one 

Relevant academic research and scientific papers

ALCOHOLYSIS OF 1,2-BIS(1-ISOCYANATO-1-METHYLETHYL)DIAZENE: UNEXPECTED FORMATION OF 5,5-DIMETHYL-1,2,4-TRIAZOLIN-2-ONE

From the reaction of the bis(isocyanatoalkyl)diazene 1 with alcohols the expected adducts 2 could not be isolated (though there is spectroscopic evidence of their formation).The main product obtained was the triazolin-3-one 3, and in addition, several complementing products 4-6 were formed.

Efficient Synthesis of 5,5-Dialkyl-Δ1-1,2,4-triazolin-3-ones by Acid Hydrolysis of Bis(α-isocyanatoalkyl)diazenes

The hydrolysis of bis(α-isocyanatoalkyl)diazenes with hydrochloric acid affords the novel 5,5-dialkyl-Δ1-1,2,4-triazolin-3-ones in good yields, and as a minor by-product, the corresponding 4-aminocarbonyl derivatives.The 1,2,4-triazolin-3-ones are easily converted into the 4-benzoyl derivatives which, in turn, react as mild benzoylating agents toward primary amines.