1127955-67-2Relevant academic research and scientific papers
Indoles synthesized from amines via copper catalysis
Besandre, Ronald,Jaimes, Miguel,May, Jeremy A.
supporting information, p. 1666 - 1669 (2013/06/26)
N-Substituted indoles are synthesized from primary amines through a tandem reaction sequence. Initial condensation of the amine with an α-(o-haloaryl)ketone or aldehyde is followed by intramolecular aryl amination catalyzed by CuI. A variety of anilines and alkyl amines, including those with significant steric demands, are converted to indoles in high yields and with varying indole substitution.
New preparation of benzylic aluminum and zinc organometallics by direct insertion of aluminum powder
Bluemke, Tobias D.,Groll, Klaus,Karaghiosoff, Konstantin,Knochel, Paul
supporting information; experimental part, p. 6440 - 6443 (2012/01/15)
The reaction of commercial Al-powder (3 equiv) and InCl3 (1-5 mol %) with benzylic chlorides provides various functionalized benzylic aluminum sesquichlorides under mild conditions (THF, 20 °C, 3-24 h) without homocoupling (5%). These new benz
Preparation of functionalized organomanganese(II) reagents by direct insertion of manganese to aromatic and benzylic halides
Peng, Zhihua,Knochel, Paul
supporting information; experimental part, p. 3198 - 3201 (2011/08/06)
Functionalized arylmanganese compounds were prepared using commercial manganese powder in the presence of LiCl and catalytic amounts of both 2.5% InCl3 and 2.5% PbCl2 (THF, 0-50 °C). In addition, benzylic manganese reagents are obtained at 25 °C in ca. 70-80% yield (in the absence of LiCl) using commercial manganese powder and catalytic amounts of 2.5% InCl3 and 2.5% PbCl2. The resulting organomanganese reagents undergo smooth 1,2-addition, acylation, allylic substitution, Pd-catalyzed cross-coupling, and copper-catalyzed conjugate addition, affording the desired products in good yields.
Iron and copper salts in the synthesis of benzo[b]furans
Bonnamour, Julien,Piedrafita, Maria,Bolm, Carsten
supporting information; experimental part, p. 1577 - 1581 (2010/09/05)
Intramolecular C-O bond forming reactions of aryl 2-bromobenzyl ketones lead to benzo[b]furans. The cyclizations can be catalyzed by 10 mol% of iron trichloride (of 98% or of 99.995% purity) or sub-mol% quantities of copper(II) chloride (of 99.995% purity
Synthesis of benzo[b]furans by palladium-NHC catalyzed ring closure of o-bromobenzyl ketones
Farago, Janos,Kotschy, Andras
experimental part, p. 85 - 90 (2009/06/18)
The palladium-catalyzed ring closure of aryl o-bromobenzyl ketones, easily accessible from aromatic aldehydes and 2- bromobenzyl bromide, provides a straightforward route to 2-aryl- benzofurans. A study of the ring closure revealed that a heterocyclic car
