112807-11-1

Basic information

• Product Name: 3-(ChloroMethyl)-1,2,4-thiadiazol-5-aMine
• Synonyms: 3-(ChloroMethyl)-1,2,4-thiadiazol-5-aMine
• CAS NO: 112807-11-1
• Molecular Formula: C₃H₄ClN₃S
• Molecular Weight: 149.60196
• Mol File: 112807-11-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(ChloroMethyl)-1,2,4-thiadiazol-5-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(ChloroMethyl)-1,2,4-thiadiazol-5-aMine(112807-11-1)
• EPA Substance Registry System: 3-(ChloroMethyl)-1,2,4-thiadiazol-5-aMine(112807-11-1)

Safety Data

• Hazardous Substances Data: 112807-11-1(Hazardous Substances Data)

Upstream product

• 74461-64-6 3-chloromethyl-5-chloro-(1,2,4)-thiadiazole 
• 333-20-0 potassium thioacyanate 
• 10300-69-3 2-chloroacetamidine hydrochloride 

Downstream Products

• 1108713-13-8 3-(chloromethyl)-N-[(2,4-dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine 
• 1001190-30-2 O-(5-amino-1,2,4-thiadiazol-3-yl)methyl-(3-chlorophenyl-5-methyltetrazol-1-yl)methanone oxime 

Relevant articles and documents

Thiadiazole amide compound and application thereof

The invention discloses a thiadiazole amide compound and application thereof, and belongs to the field of medicines. The structural general formula of the compound is shown as a formula (I) and is a novel compound with androgen receptor antagonistic activity, wherein one of the key targets is a binding pocket between the androgen receptor ligand binding domain dimer interface. The compound provided by the invention has high activity for antagonizing the transcription of androgen receptor and is at the molecular level. The cell level and the animal level all show good biological activity, and have better safety. , The invention can be applied to the preparation of drugs for treating androgen receptor abnormal expression tumors, including but not limited to prostate cancer, metastatic prostate cancer, castration-resistant prostate cancer, breast cancer and ovarian cancer.

ANTIBACTERIAL HETEROCYCLIC UREAS

The present invention provides novel heterocyclic urea compounds having useful antibacterial activity, pharmaceutical compositions comprising one or more of these compounds, methods of making the same, and methods of using the same.