74461-64-6

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
5-CHLORO-3-(CHLOROMETHYL)-1,2,4-THIADIAZOLE is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique chemical structure allows for the development of new compounds with potential therapeutic and pesticidal properties.
Used in Antibacterial and Antifungal Applications:
5-CHLORO-3-(CHLOROMETHYL)-1,2,4-THIADIAZOLE has been studied for its potential activity as an antibacterial and antifungal agent. Its ability to inhibit the growth of harmful microorganisms makes it a promising candidate for the development of new antimicrobial agents.
Used in Material Science:
5-CHLORO-3-(CHLOROMETHYL)-1,2,4-THIADIAZOLE has shown potential for use in the development of new materials for various industrial applications. Its unique chemical properties may contribute to the creation of innovative materials with improved performance characteristics.
Used in Research and Development:
Due to its potential biological and industrial significance, 5-CHLORO-3-(CHLOROMETHYL)-1,2,4-THIADIAZOLE is a compound of interest for further research and development. Continued investigation into its properties and applications may lead to the discovery of new uses and advancements in various fields.

InChI:InChI=1/C3H2Cl2N2S/c4-1-2-6-3(5)8-7-2/h1H2

Upstream product

• 10300-69-3 2-chloroacetamidine hydrochloride 
• 594-42-3 chlorothio-trichloro-methane 
• 20846-52-0 2-chloro-acetamidine 
• 75-70-7 trichloromethyl mercaptan 

Downstream Products

• 112807-11-1 3-(chloromethyl)-1,2,4-thiadiazol-5-amine 
• 1108713-13-8 3-(chloromethyl)-N-[(2,4-dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine 
• 1021533-89-0 1-(5-chloro-1,2,4-thiadiazol-3-ylmethyl)-3-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methyl-pentyl]-piperidin-4-yl}-1,3-dihydro-benzimidazol-2-one 
• 1000887-21-7 C₂₄H₂₂ClN₅O₅S₂ 

Relevant academic research and scientific papers

1,2,4- THIADIAZOL-5-THIO COMPOUNDS AND THE DERIVATIVES THEREOF, METHODS FOR THE PRODUCTION THEREOF AND USE THEREOF AS UREASE AND NITRIFICATION INHIBITORS

The invention relates to methods for the production and use of novel 1,2,4-thiadiazols of general formulae (I) or (II) as agents for regulating the inhibition of enzymatic urea hydrolysis, wherein R1 = hydrogen, C1-C8-alkyl or C6-C10-aryl and R2 = hydrogen, C1-C8- alkyl/heteroalkyl, C2-C8 -alkenyl/heteroalkenyl, C2-C8 -alkinyl/heteroalkinyl, C3-C8- cycloalkyl/heterocycloalkyl, C3-C8 -cycloalkenyl/heterocycloalkenyl, C6-C10 -aryl/heteroaryl, aralkyl, heteroarylalkyl, alkaryl, akheteroaryl, alkoxy, aryloxy, hetaryloxy, alkylthio, arylthio, hetarylthio, acyl, aroyl, hetaroyl, acyloxy, aroyloxy, hetaroyloxy, alkoxycarbonyl, aryloxycarbonyl, hetaryloxycarbonyl, amino, alkylamino, dialkylamino, alkylsulfonyl, arylsulfonyl, fluorine, chlorine, bromine, iodine, hydroxy, cyano, nitro, sulfo, carbonyl, carboxy, carbamoyl, sulfamoyl, the radicals R1 and/or R2 can, optionally, be per se and individually substituted by one or several of the above-mentioned groups. With a limited spectrum of substituents in R2, said compounds can be claimed as nitrification inhibitors. The inventive 1,2,4-thiadiazols thus used are effective urease inhibitors and have a good resistance to hydrolysis and can be produced according to known methods. They are also effective nitrification inhibitors and can delay transformation of ammonia. They are the first inhibitors which effectively eliminate the two main sources of loss during the application of manure, i.e. urease-catalyzed urea hydrolysis and nitrification of ammonia nitrogen. The inventive compounds can also be combined with more potent nitrification inhibitors, whereby nitrogen losses can also be reduced, without any problem.

Oxazoles and their agricultural compositions

A compound having the formula R--S(O)n CH2 CH2 CH=CF2, wherein R is a phenyl group or a heterocyclic group selected from furyl, thienyl, isoxazolyl, isothiazolyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, 1,2,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1,3,4-oxadiazolyl, 1,3,4-thidiazolyl, tetrazolyl, pyridyl, pyridazinyl, pyrazinyl, 1,2,3-triazinyl, 1,3,4-triazinyl, and 1,3,5-triazinyl groups, said phenyl or heterocyclic group being optionally substituted by optionally substituted alkyl, optionally substituted alkenyl, alkynyl, cycloalkyl, alkylcycloalkyl, alkoxy, alkenyloxy, alkynyloxy, hydroxyalkyl, alkoxyalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted aryloxy, optionally substituted arylalkoxy, optionally substituted aryloxyalkyl, optionally substituted heteroaryloxy, optionally substituted heteroarylalkoxy, optionally substituted heteroaryloxyalkyl, haloalkyl, haloalkenyl, haloalkynyl, haloalkoxy, haloalkenyloxy, haloalkynyloxy, halogen, hydroxy, cyano, nitro, --NR7R8, --NR7COR8, --NR7CSR8, --NR7SO2R8, --N(SO2R7)(SO2R8), --COR7, --CONR7R8, -alkylCONR7R8, --CR7NR8, --COOR7, --OCOR7, --SR7, --SOR7, --SO2R7, -alkylSR7, -alkylSOR7, -alkylSO2R7, --OSO2R7, --SO2NR7R8, --CSNR7R8, --SiR7R8R9, --OCH2CO2R7, --OCH2CH2CO2R7, --CONR7SO2R8, -alkylCONR7SO2R8, --NHCONR7R8, --NHCSNR7R8, or an adjacent pair of R1, R2, R3, R4, R5 and R6 when taken together form a fused 5- or 6-membered carbocyclic or heterocyclic ring; R7, R8 and R9 are each independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, alkynyl, optionally substituted aryl or optionally substituted arylalkyl, haloalkyl, haloalkenyl, haloalkynyl, halogen or hydroxy.

Antisecretory thiadiazole derivatives, processes for their manufacture and pharmaceutical compositions containing them

The invention relates to a thiadiazole derivative of the formula I: STR1 in which Y is O, S, CH2, SO or a direct bond; m is 0 to 4 and n is 1 to 4 provided that when Y is S, O or SO m is 1 to 4, and when Y is O or SO n is 2 to 4; R1 is H or (C1-10)alkyl; A is 3,4-dioxocyclobuten-1,2-diyl or C=Z in which Z is O, S, NCN, NNO2, CHNO2, NCONH2, C(CN)2, NCOR2, NCO2 R2, NSO2 R2 or NR3 in which R2 is (C1-6)alkyl or (C6-12)aryl and R3 is H or C1-6)alkyl; B is (C1-6)alkoxy, (C1-6)alkylthio or NR4 R5 in which R4 and R5 are independently H, (C1-10)alkyl, C3-6 (alkenyl), (C3-6)alkynyl, (C2-6)(primary hydroxy)alkyl, (C2-6)(primary amino)alkyl or C3-6)cycloalkyl or R4 and R5 are joined to form a 5- or 6- membered saturated ring optionally containing an additional O or NH: and the salts thereof.