113075-86-8

Usage

Uses

Used in Pharmaceutical Industry:
6,8-Dichloro-2-tetralone is used as a key reactant for the preparation of tetrahydrospiro[imidazolenaphthalenes], which are known as α-adrenergic agonists. These compounds play a crucial role in the development of medications targeting the adrenergic system, which is involved in various physiological processes, including blood pressure regulation, bronchodilation, and neurotransmission.

Upstream product

• 74-85-1 ethene 
• 53056-20-5 2,4-dichlorophenylacetyl chloride 
• 1777-82-8 (2,4-dichlorophenyl)methanol 
• 50-84-0 2,4 dichlorobenzoic acid 
• 6574-98-7 2,4-dichlorobenzylnitrile 
• 19719-28-9 2,4-dichlorophenylacetic acid 
• 20443-99-6 2,4-dichlorobenzyl bromide 

Relevant academic research and scientific papers

Technological method for preparing halogenated-3,4-dihydro-1H-2-naphthalenone

The invention relates to a technological preparation method of halogenated-3,4-dihydro-1H-2-naphthalenone as shown in a formula (I). (As shown in the description). According to the method disclosed by the invention, through a cheap raw material namely 2,4-dihalogeno-benzene carbonitrile, and an intermediate namely 2,4-dihalogeno-benzene acetic acid is synthesized, and through a reusable trifluoroacetic anhydride/acid system catalyst, a target product namely the halogenated-3,4-dihydro-1H-2-naphthalenone is synthesized. According to the method disclosed by the invention, a large quantity of catalysts such as aluminumtrichloride, and costly catalysts such as Rh, are not needed, and the reaction route can be shortened, so that a large quantity of reagents and time can be saved, and the industrial economic benefits can be greatly increased.

Benzazecine derivatives for cognitive and memory functions

Benzazecinediones of the formula STR1 wherein R1 and R2 are independently hydrogen or chlorine, R3 is hydrogen, fluorine, chlorine, bromine or methoxy, R4 is hydrogen, chlorine or methoxy and R5 is hy