31557-57-0

Basic information

• Product Name: 2-CHLORO-3-PHENYLPYRIDINE
• Synonyms: 2-CHLORO-3-PHENYLPYRIDINE
• CAS NO: 31557-57-0
• Molecular Formula: C₁₁H₈ClN
• Molecular Weight: 189.64
• Mol File: 31557-57-0.mol
• Article Data: 10

Chemical Properties

• Melting Point: 55-56℃
• Boiling Point: 296℃
• Flash Point: 161℃
• Appearance: /
• Density: 1.186
• Vapor Pressure: 0.00255mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: 2-CHLORO-3-PHENYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-3-PHENYLPYRIDINE(31557-57-0)
• EPA Substance Registry System: 2-CHLORO-3-PHENYLPYRIDINE(31557-57-0)

Safety Data

• Hazardous Substances Data: 31557-57-0(Hazardous Substances Data)

Usage

General Description

2-Chloro-3-phenylpyridine is a chemical compound with the molecular formula C11H8ClN. It is an organic compound containing a pyridine ring with a chlorine atom and a phenyl group attached to different carbon atoms. This chemical is commonly used as a building block in the synthesis of pharmaceutical products and fine chemicals. It has applications in the pharmaceutical industry for the production of medicines and drugs, as well as in the research and development of new chemical compounds. 2-Chloro-3-phenylpyridine is known for its role as an intermediate in organic synthesis and is used in various chemical reactions to create more complex molecules.

InChI:InChI=1/C11H8ClN/c12-11-10(7-4-8-13-11)9-5-2-1-3-6-9/h1-8H

Upstream product

• 2942-59-8 2-chloronicotinic acid 
• 71-43-2 benzene 
• 52200-48-3 3-bromo-2-chloropyridine 
• 98-80-6 phenylboronic acid 
• 21352-19-2 N-(2-chloro-3-pyridinyl)acetamide 
• 1131-48-2 3-phenylpyridine N-oxide 
• 103863-15-6 3-phenylpyridine-2-carboxylic acid 

Downstream Products

• 1357159-20-6 1-amino-2-(4-(1-(tert-butoxycarbonylamino)cyclobutyl)phenyl)-3-phenylpyridinium 2,4,6-trimethylbenzenesulfonate 
• 1357159-21-7 methyl 7-(4-(1-(tert-butoxycarbonylamino)cyclobutyl)phenyl)-6-phenylpyrazolo[1,5-a]pyridine-3-carboxylate 
• 1357158-73-6 1-(4-(6-phenylpyrazolo[1,5-a]pyridin-7-yl)phenyl)cyclobutanamine 
• 1357159-18-2 tert-butyl 1-(4-(3-phenylpyridin-2-yl)phenyl)cyclobutylcarbamate 
• 104813-63-0 4-{4-[4-(3-Phenyl-pyridin-2-yl)-piperazin-1-yl]-butyl}-morpholine-3,5-dione 
• 104813-61-8 3-{4-[4-(3-Phenyl-pyridin-2-yl)-piperazin-1-yl]-butyl}-1-thia-3-aza-spiro[4.4]nonane-2,4-dione 
• 104813-67-4 4,4-dimethyl-1-[4-[4-(3-phenyl-2-pyridinyl)-1-piperazinyl]butyl]-2,6-piperidinedione 
• 53698-45-6 2-methoxy-3-phenylpyridine 

Relevant articles and documents

Synthesis of heterobiaryls via Suzuki-Miyaura coupling reaction of potassium aryltrifluoroborates with heteroaryl halides in aqueous systems

A variety of heterobiaryl compounds have been synthesized by the Suzuki-Miyaura coupling reactions of heteroaryl halides with potassium aryltrifluoroborates. Pd (OAc)2 was found to be highly efficient for the Suzuki-Miyaura coupling reactions of various heteroaryl halides with potassium aryltrifluoroborates in aqueous systems, delivering the corresponding heterobiaryl compounds in good to excellent yields.

Stereodivergent Photoelectrocyclization Reactions of Bis-aryl Cycloalkenones: Intercepting Photoelectrocyclization Intermediates with Acid

Described here are tandem photoelectrocyclization and [1,5]-hydride shift reactions of heteroaryl-containing bis-aryl cyclohexenone derivatives that give heteroaryl-substituted dihydrophenanthrenes. This Letter demonstrates that electrocyclization intermediates can be trapped with acid when the [1,5]-hydride shift is relatively slow. From a practical perspective, the observation that the acid-mediated reaction gives a divergent stereochemical outcome when compared with the reaction run under neutral conditions makes these transformations powerful.

Mild, visible light-mediated decarboxylation of aryl carboxylic acids to access aryl radicals

Herein we present the first example of aryl radical formation via the visible light-mediated decarboxylation of aryl carboxylic acids using photoredox catalysis. This method constitutes a mild protocol for the decarboxylation of cheap and abundant aryl carboxylic acids and tolerates both electron-rich substrates and those lacking ortho-substitution. The in situ formation of an acyl hypobromite is proposed to prevent unproductive hydrogen atom abstraction and trapping of the intermediate aroyloxy radical, enabling mild decarboxylation.