113160-00-2

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 13107-39-6 2-(4-methylphenyl)oxirane 
• 5720-07-0 4-methoxyphenylboronic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 104-82-5 4-Methylbenzyl chloride 
• 186581-53-3 diazomethane 
• 110995-90-9 4-(1-Hydroxy-2-p-tolyl-ethyl)-phenol 

Downstream Products

• 57297-25-3 1-(4-methoxyphenyl)-2-(4-methylphenyl)ethanone 

Relevant academic research and scientific papers

Ceric Ammonium Nitrate Oxidative-Cleavage Reaction of Some Lignin Model Compounds: Role of the Benzylic Hydroxyl Group

A series of β-1 lignin model compounds was synthesized and then oxidized with ceric ammonium nitrate (CAN) in aqueous acetonitrile.The compounds studied were 1,2-diarylethanols with either a p-hydroxy (1a-e) or a p-methoxy (2a-e) on the 1-ring and the following para substituents on the 2-ring: (a) H, (b) Cl, (c) Me, (d) OMe, and (e) NO2.Reactions of p-hydroxyl compounds 1a-e with CAN resulted in the formation of a red cerium complex that did not oxidize under the conditions of the reaction.In contrast all of the methoxy compounds 2a-e were rapidly oxidized by CAN atroom temperature to give p-anisaldehyde in near quatitative yield.The relative rates of these oxidative-cleavage reactions were found to be 0.11, 0.16, 1.00, 1.58, and 2.37 for the 1,2-diarylethanols 2e, 2b, 2a, 2c, and 2d, respectively.A Hammett treatment of this data revealed an excellent correlation with ?(ρ = -1.24).Methylation of the benzylic hydroxy group of 2a gave 1-methoxy-1-(4-methoxyphenyl)-2-phenylethane, which was found to be inert to CAN oxidation.

Nickel-catalyzed cross-coupling of styrenyl epoxides with boronic acids

Let's get multicatalytic! A Ni0 catalyst complexed with a biaryldialkyl monophosphine ligand facilitates C-C bond formation between styrenyl epoxides and aryl boronic acids (see scheme). X-ray analysis of a catalytically active nickel/ligand complex supports a redox pathway involving C sp 3-O bond activation. A variety of α-substituted alcohols were generated with good reaction efficiency by a multicatalytic sequence. Copyright

Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles

The aim of this study was to investigate 4,5-diaryl isoselenazoles as multiple target non-steroidal anti-inflammatory drugs (MTNSAIDs) which can intervene into the inflammatory processes via different mechanisms of action creating a new class of compounds