57297-25-3

Basic information

• Product Name: Ethanone, 1-(4-methoxyphenyl)-2-(4-methylphenyl)-
• CAS NO: 57297-25-3
• Molecular Formula: C16H16O2
• Molecular Weight: 240.302
• Mol File: 57297-25-3.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(4-methoxyphenyl)-2-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(4-methoxyphenyl)-2-(4-methylphenyl)-(57297-25-3)
• EPA Substance Registry System: Ethanone, 1-(4-methoxyphenyl)-2-(4-methylphenyl)-(57297-25-3)

Safety Data

• Hazardous Substances Data: 57297-25-3(Hazardous Substances Data)

Upstream product

• 100-66-3 methoxybenzene 
• 35675-44-6 4-methylphenylacetyl chloride 
• 622-47-9 4-tolylacetic acid 
• 24785-38-4 1-methoxy-4-[2-(4-methylphenyl)ethynyl]benzene 
• 108-88-3 toluene 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 2947-61-7 (4-methylphenyl)acetonitrile 
• 5720-07-0 4-methoxyphenylboronic acid 
• 106-38-7 para-bromotoluene 
• 33425-19-3 1-(4-methoxyphenyl)-2-(4-methylphenyl)ethane-1,2-dione 
• 106-43-4 para-chlorotoluene 
• 3319-15-1 rac-1-(4-methoxyphenyl)-ethanol 
• 113160-00-2 1-(4-methoxyphenyl)-2-(4-methylphenyl)ethanol 
• 104-87-0 4-methyl-benzaldehyde 

Downstream Products

• 1041810-71-2 (Z)-3-chloro-3-(4-methoxyphenyl)-2-(p-tolyl)propenal 
• 33425-19-3 1-(4-methoxyphenyl)-2-(4-methylphenyl)ethane-1,2-dione 
• 99-94-5 p-Toluic acid 
• 100-09-4 4-methoxybenzoic acid 
• 866181-45-5 2-bromo-1-(4-methoxyphenyl)-2-(p-tolyl)ethan-1-one 
• 1268607-02-8 (E)-1-methyl-4-(3,3,3-trifluoro-2-phenylprop-1-enyl)benzene 

Relevant articles and documents

Thianthrenation-enabled α-arylation of carbonyl compounds with arenes

The Pd-catalyzed α-arylation of carbonyl compounds with simple arenes enabled by site-selective thianthrenation has been demonstrated. This onepot process using thianthrenium salts as the traceless arylating reagents features mild conditions and a broad substrate scope. In addition, this protocol could also tolerate the heterocyclic carbonyl compounds and complex bioactive molecules, which is appealing for medicinal chemistry.

Two-Step One-Pot Synthesis of Unsymmetrical (Hetero)Aryl 1,2-Diketones by Addition-Oxygenation of Potassium Aryltrifluoroborates to (Hetero)Arylacetonitriles

An efficient one-pot two-step procedure for the synthesis of unsymmetrical (hetero)aryl 1,2-diketones has been developed. The reaction proceeds through a palladium-catalyzed nucleophilic addition of potassium aryltrifluoroborates to aliphatic nitriles followed by a copper-catalyzed aerobic benzylic C–H oxygenation using molecular oxygen as a green oxidant. This represents the first example of the direct synthesis of unsymmetrical diaryl 1,2-diketones from arylacetonitriles. This method utilizes inexpensive, stable, nontoxic, and readily available starting materials, is highly effective in the presence of both electron-rich and electron-poor nitriles and aryltrifluoroborates, and tolerates a wide variety of functional groups. The synthetic utility of this transformation was shown by increasing the scale of the reaction and by carrying out the one-pot protocol for the preparation of quinoxaline and benzimidazole derivatives. A plausible reaction mechanism has also been proposed.

Nickel catalyzed α-arylation of ketones with aryltrimethylammonium triflates

Nickel-catalyzed α-arylation of ketones involving aromatic C-N cleavage has been accomplished. Intermolecular coupling of aromatic ketones with a variety of aryltrimethylammonium triflates was achieved in the presence of Ni(COD)2, IPr·HCl, and LiOBut, giving α-arylated ketones in reasonable to excellent yields.