113209-90-8

Basic information

• Product Name: 4-CHLORO-5-FLUORO-2-PYRIDINEMETHANOL
• Synonyms: 4-CHLORO-5-FLUORO-2-PYRIDINEMETHANOL;2-Pyridinemethanol,4-chloro-5-fluoro-;(4-Chloro-5-fluoropyridin-2-yl)methanol;4-Chloro-5-fluoro-2-(hydroxymethyl)pyridine;(4-Chloro-5-fluoropyridin-2-yl)
• CAS NO: 113209-90-8
• Molecular Formula: C6H5ClFNO
• Molecular Weight: 161.56
• Mol File: 113209-90-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 231.2°C at 760 mmHg
• Flash Point: 93.6°C
• Appearance: /
• Density: 1.434g/cm³
• Vapor Pressure: 0.0352mmHg at 25°C
• Refractive Index: 1.546
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 12.72±0.10(Predicted)
• CAS DataBase Reference: 4-CHLORO-5-FLUORO-2-PYRIDINEMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-5-FLUORO-2-PYRIDINEMETHANOL(113209-90-8)
• EPA Substance Registry System: 4-CHLORO-5-FLUORO-2-PYRIDINEMETHANOL(113209-90-8)

Safety Data

• Hazardous Substances Data: 113209-90-8(Hazardous Substances Data)

Usage

General Description

4-CHLORO-5-FLUORO-2-PYRIDINEMETHANOL is a chemical compound with the molecular formula C6H5ClFNO. It is a derivative of pyridine and contains a chlorine and fluorine atom attached to the pyridine ring. 4-CHLORO-5-FLUORO-2-PYRIDINEMETHANOL is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It possesses both chloro and fluoro substitutions, which make it a valuable building block in organic synthesis. Additionally, it has been found to exhibit antimicrobial and antifungal properties, making it potentially useful in the development of new drugs for treating infections.

InChI:InChI=1/C6H5ClFNO/c7-5-1-4(3-10)9-2-6(5)8/h1-2,10H,3H2

Upstream product

• 80287-53-2 5-Amino-2-methylpyridine 
• 108-24-7 acetic anhydride 
• 113209-89-5 4-chloro-5-fluoro-2-methylpyridin-1-ium-1-olate 
• 113209-88-4 5-fluoro-2-methyl-4-nitropyridine 1-oxide 
• 45673-79-8 2‐methyl‐5‐fluoropyridine 1‐oxide 
• 31181-53-0 2‐methyl‐5‐fluoropyridine 

Relevant articles and documents

NOVEL OXALYL PIPERAZINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

Compounds

Compounds of Formula (I), compositions containing them, their use in therapy, including their use as antibacterials, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.

2-[[(4-Amino-2-pyridyl)methyl]sulfinyl]benzimidazole H+/K+-ATPase inhibitors. The relationship between pyridine basicity, stability, and activity

The benzimidazole sulfoxide class of antisecretory H+/K+-ATPase inhibitors need to possess high stability under neutral physiological conditions yet rearrange rapidly at low pH to the active sulfenamide 2. Since the initial reaction involves internal nucleophilic attack by the pyridine nitrogen, control of the pyridine pK(a) is critical. In this paper we show that by utilizing the powerful electron-donating effect of a 4-amino substituent on the pyridine, moderated by the electron-withdrawing effect of a 3- or 5-halogen substituent, a combination of high potency (as inhibitors of histamine-stimulated gastric acid secretion) and good stability under physiological conditions can be obtained. Furthermore, the role of the steric interaction between the 3/5-substituents and the 4-substituent in modifying the electron-donating ability of the 4-amino group is exemplified, and additional factors affecting stability are identified. One compound, in particular, 2-[[(3-chloro-4-morpholino-2-pyridyl)methyl]sulfinyl]-5-methoxy-(1H)- benzimidazole (3a, SK and F 95601), was chosen for further development and evaluation in man.