113209-90-8

Usage

Uses

Used in Pharmaceutical Synthesis:
4-CHLORO-5-FLUORO-2-PYRIDINEMETHANOL is used as a key intermediate in the production of various pharmaceuticals. Its unique structural features, including the presence of chloro and fluoro substitutions, make it an essential building block in the organic synthesis of drugs with diverse therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, 4-CHLORO-5-FLUORO-2-PYRIDINEMETHANOL serves as an intermediate for the synthesis of compounds with pesticidal properties. Its chemical structure allows for the development of new agrochemicals that can effectively control pests and diseases in agriculture.
Used in Antimicrobial Drug Development:
4-CHLORO-5-FLUORO-2-PYRIDINEMETHANOL is used as a starting material in the development of new antimicrobial drugs. Its inherent antimicrobial and antifungal properties suggest its potential use in creating novel treatments for infections caused by resistant bacteria and fungi.
Used in Antifungal Drug Development:
Similarly, the antifungal properties of 4-CHLORO-5-FLUORO-2-PYRIDINEMETHANOL make it a valuable component in the development of antifungal medications. It can be utilized to formulate new drugs that address the growing issue of fungal resistance and improve treatment options for various fungal infections.

InChI:InChI=1/C6H5ClFNO/c7-5-1-4(3-10)9-2-6(5)8/h1-2,10H,3H2

Upstream product

• 108-24-7 acetic anhydride 
• 113209-89-5 4-chloro-5-fluoro-2-methylpyridin-1-ium-1-olate 
• 113209-88-4 5-fluoro-2-methyl-4-nitropyridine 1-oxide 
• 80287-53-2 5-Amino-2-methylpyridine 
• 45673-79-8 2‐methyl‐5‐fluoropyridine 1‐oxide 
• 31181-53-0 2‐methyl‐5‐fluoropyridine 

Relevant academic research and scientific papers

NOVEL OXALYL PIPERAZINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

NOVEL INDOLIZINE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

2-[[(4-Amino-2-pyridyl)methyl]sulfinyl]benzimidazole H+/K+-ATPase inhibitors. The relationship between pyridine basicity, stability, and activity

The benzimidazole sulfoxide class of antisecretory H+/K+-ATPase inhibitors need to possess high stability under neutral physiological conditions yet rearrange rapidly at low pH to the active sulfenamide 2. Since the initial reaction involves internal nucleophilic attack by the pyridine nitrogen, control of the pyridine pK(a) is critical. In this paper we show that by utilizing the powerful electron-donating effect of a 4-amino substituent on the pyridine, moderated by the electron-withdrawing effect of a 3- or 5-halogen substituent, a combination of high potency (as inhibitors of histamine-stimulated gastric acid secretion) and good stability under physiological conditions can be obtained. Furthermore, the role of the steric interaction between the 3/5-substituents and the 4-substituent in modifying the electron-donating ability of the 4-amino group is exemplified, and additional factors affecting stability are identified. One compound, in particular, 2-[[(3-chloro-4-morpholino-2-pyridyl)methyl]sulfinyl]-5-methoxy-(1H)- benzimidazole (3a, SK and F 95601), was chosen for further development and evaluation in man.