113264-13-4

Basic information

• Product Name: 4-(chloromethyl)-2-(4-fluorophenyl)-1,3-thiazole(SALTDATA: FREE)
• Synonyms: 4-(chloromethyl)-2-(4-fluorophenyl)-1,3-thiazole(SALTDATA: FREE);4-(chloromethyl)-2-(4-fluorophenyl)thiazole
• CAS NO: 113264-13-4
• Molecular Formula: C10H7ClFNS
• Molecular Weight: 227.6856832
• Mol File: 113264-13-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(chloromethyl)-2-(4-fluorophenyl)-1,3-thiazole(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(chloromethyl)-2-(4-fluorophenyl)-1,3-thiazole(SALTDATA: FREE)(113264-13-4)
• EPA Substance Registry System: 4-(chloromethyl)-2-(4-fluorophenyl)-1,3-thiazole(SALTDATA: FREE)(113264-13-4)

Safety Data

• Hazardous Substances Data: 113264-13-4(Hazardous Substances Data)

Upstream product

• 1194-02-1 4-fluorobenzonitrile 
• 22179-72-2 4-fluorothiobenzamide 
• 534-07-6 1,3-Dichloroacetone 
• 132089-35-1 ethyl 2-(4-fluorophenyl)thiazole-4-carboxylate 
• 824-75-9 p-fluorobenzamide 

Downstream Products

• 1589081-07-1 4-amino-6-(benzo[d][1,3]dioxol-5-yl)-2-((2-(4-fluorophenyl)thiazol-4-yl)methylthio)pyrimidine-5-carbonitrile 

Relevant articles and documents

Discovery of 3,5-dimethylisoxazole derivatives as novel, potent inhibitors for bromodomain and extraterminal domain (BET) family

Bromodomain and extra-terminal (BET) is a promising therapeutic target for various hematologic cancers. We used the BRD4 inhibitor compound 13 as a lead compound to develop a variety of compounds, and we introduced diverse groups into the position of the compound 13 orienting toward the ZA channel. A series of compounds (14–23, 38–41, 43, 47–49) bearing triazolopyridazine motif exhibited remarkable BRD4 protein inhibitory activities. Among them, compound 39 inhibited BRD4(BD1) protein with an IC50 of 0.003 μM was superior to lead compound 13. Meanwhile, compound 39 possess activity, IC50 = 2.1 μM, in antiproliferation activity against U266 cancer cells. On the other hand, compound 39 could arrest tumor cells into the G0/G1 phase and induce apoptosis, which was consistent with its results in inhibiting cell proliferation. Biological and biochemical data suggest that BRD4 protein might be a therapeutic target and that compound 39 is an excellent lead compound for further development.

Substituted pyrimidine compound and application thereof

The present invention discloses a substituted pyrimidine compound, which has a structure represented by a general formula I, wherein each substituent is defined in the specification. According to thepresent invention, the compound has a broad-spectrum bactericidal activity, can provide excellent prevention and control effects on cucumber downy mildew, wheat powdery mildew, corn rust disease, riceblast, cucumber anthracnose and the like, and particularly can provide good prevention effects on powdery mildew, corn rust disease and rice blast.

COMPOUNDS AND METHODS for the inhibition of HDAC

Disclosed are compounds having the formula: wherein X1, X2, X3, R1, R2, R3, R4, Y, A, Z, L and n are as defined herein, and methods of making and using the same.