113266-23-2

Upstream product

• 4070-48-8 L-Valine methyl ester 
• 1170-76-9 Z-Gly-(L)-Phe 
• 6306-52-1 L-valine methylester hydrochloride 
• 63-91-2 L-phenylalanine 
• 54648-79-2 N,N’-diisopropyl-O-methylisourea 
• 1160842-83-0 (L,L)-Cbz-Gly-Phe-Val-OH 
• 1330059-32-9 N-benzyloxycarbonylglycine-L-phenylalanine 9-fluorenylmethyl thioester 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 67-56-1 methanol 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 

Relevant academic research and scientific papers

Use of 1-β-Naphthalenesulfonyloxybenzotriazole As Coupling Reagent in Solid Phase Peptide Synthesis

Application of 1-β-naphthalenesulfonyloxybenzotriazole (NSBt) as an efficient coupling reagent in solid phase is reported.It has been found to be suitable for the rapid and quantitative coupling of various amino acid derivatives.

Peptide bond formation using polymer-bound BOP

A new polymer-supported BOP (P-BOP) has been prepared starting from the commercially available polystyrene-bound 1-hydroxybenzotriazole (P-HOBt) and successfully used as a solid-supported reagent for peptide-coupling reactions. Compared to BOP, less epime

NEW COUPLING REAGENTS IN PEPTIDE CHEMISTRY

2-(1H-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU) has been applied as coupling reagent to solid phase peptide synthesis.Furthermore, a general synthetic procedure for new derivatives of different N-hydroxy compounds has been developed.They either act as excellent activating reagents causing low racemization during condensation of peptide segments or are useful tools for the formation of active esters suitable for couplings in mixed aqueous / organic media, respectively.

HOBt and HOAt-derived immonium salts: New and highly efficient coupling reagents for peptide synthesis

Novel HOBt- and HOAt-derived immonium type coupling reagents BDMP, BPMP and AOMP were shown to be very efficient for peptide synthesis with high reactivity, low racemization and good yields. X-Ray analysis indicates BOMI exists as the N-substituted form r

Aerobic, Diselenide-Catalyzed Redox Dehydration: Amides and Peptides

At 2.5 mol % loadings using reaction temperatures between 30-55 °C, ortho-functionalized diaryl diselenides are highly effective organocatalytic oxidants for aerobic redox dehydrative amidic and peptidic bond formation using triethyl phosphite as a simple terminal reductant. This simple-to-perform organocatalytic reaction relies on the ability of selenols to react directly with dioxygen in air without recourse to metal catalysts. It represents an important step toward the development of a general, economical, and benign catalytic redox dehydration protocol.

New and highly efficient immonium type peptide coupling reagents: Synthesis, mechanism and application

A series of novel immonium type coupling reagents BOMI, BDMP, BPMP, DOMP, SOMP, FOMP and AOMP were designed and synthesized. It was shown that most of these reagents were more efficient in peptide synthesis than conventional methods due to the advantages

PENTAFLUOROPHENYL DIPHENYLPHOSPHINATE A NEW EFFICIENT COUPLING REAGENT IN PEPTIDE CHEMISTRY

Pentafluorophenyl diphenylphosphinate was found to be a new efficient coupling reagent for the racemization-free synthesis of peptides.It has been applied in both the solution and the solid phase peptide synthesis.

Efficient amounts of additives for peptide coupling mediated by a water-soluble carbodiimide in aqueous media

The optimal amounts of HOBt, HOSu, and HONb for enhancement of peptide coupling mediated by EDC in aqueous media were found to be less than equimolar against the C-component or the carbodiimide. A combination of EDC and 0.1 equimolar amount of HOBt was sh

A new coupling reagent for peptide synthesis. Benzotriazolvyloxy-bis (pyrroltdino) -carbonium hexaflouorophosphate (BBC)

Benzotriazolyloxy-bis(pyrrolidino)-carbonium hexa- fluorophosphate (BBC) is found to be a new excellent coupling reagent devoid of cytotoxic by-product instead of HBTU and BOP. It has been applied in the solution and solid phase peptide synthesis.

S-(2-Pyrimidinyl)- and S-(2-(4,6-dimethylpyrimidinyl))-1,1,3,3- tetramethylthiouronium hexafluorophosphates: Novel reagents for in situ peptide coupling

Two new reagents for in situ peptide coupling based on the 2-mercaptopyrimidine core have been developed. The readily prepared thiouronium salts were found to promote both peptide and segment coupling efficiently with low racemization/epimerization levels