113290-32-7

Basic information

• Product Name: Benzoic acid, 2-[[(dimethylamino)methylene]amino]-, methyl ester (9CI)
• Synonyms: Benzoic acid, 2-[[(dimethylamino)methylene]amino]-, methyl ester (9CI)
• CAS NO: 113290-32-7
• Molecular Formula: C₁₁H₁₄N₂O₂
• Molecular Weight: 206.24106
• Product Categories: AMINOACID
• Mol File: 113290-32-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 90-100 °C(Press: 0.2 Torr)
• Appearance: /
• Density: 1.04±0.1 g/cm3(Predicted)
• PKA: 6.84±0.30(Predicted)
• CAS DataBase Reference: Benzoic acid, 2-[[(dimethylamino)methylene]amino]-, methyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-[[(dimethylamino)methylene]amino]-, methyl ester (9CI)(113290-32-7)
• EPA Substance Registry System: Benzoic acid, 2-[[(dimethylamino)methylene]amino]-, methyl ester (9CI)(113290-32-7)

Safety Data

• Hazardous Substances Data: 113290-32-7(Hazardous Substances Data)

Upstream product

• 152904-42-2 N-(o-Carboxyphenyl)-N,N'-dimethylformamidin 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 118-92-3 anthranilic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 134-20-3 2-carbomethoxyaniline 

Downstream Products

• 16347-60-7 3-phenyl-4(3H)-quinazolinone 
• 1391098-48-8 3-(3,5-dimethoxyphenyl)quinazolin-4(3H)-one 
• 331983-26-7 3-(4-fluorophenyl)quinazolin-4-(3H)-one 
• 5388-11-4 3-benzyl-3H-quinazolin-4-one 
• 69875-49-6 4-chlro-3-cyanoquinoline 

Relevant articles and documents

Convenient one-pot synthesis of N3-substituted pyrido[2,3-d]-, pyrido[3,4-d]-, pyrido[4,3-d]-pyrimidin-4(3H)-ones, and quinazolin-4(3H)-ones analogs

A convenient microwave-assisted one-pot sequential synthesis provided access to novel pyridopyrimidin-4-(3H)-ones in good to excellent yields. Anthranilic acid, 2- and 4-aminonicotinic acids, and 3-aminoisonicotinic acid were quantitatively converted into

USE OF CYANOQUINOLINES FOR TREATING OR INHIBITING COLONIC POLYPS

This invention provides a method of treating or inhibiting colonic polyps which comprises providing a compound of formula (1); wherein R1, R2, R3, R4, X, Y, and n are defined hereinbefore, or a pharmaceutically acceptable salt thereof.

SUBSTITUTED 3-CYANO QUINOLINES

This invention provides compounds having formula (1), wherein: X is cycloalkyl which may be optionally substituted; or is a pyridinyl, pyrimidinyl, or phenyl ring; wherein the pyridinyl, pyrimidinyl, or phenyl ring may be optionally substituted; n is 0-1; Y is -NH-, -O-, -S-, or -NR-; R is alkyl of 1-6 carbon atoms; R1, R2, R3 and R4 are each, independently, hydrogen, halogen, alkyl, alkenyl, alkynyl, alkenyloxy, alkynyloxy, hydroxymethyl, halomethyl, alkanoyloxy, alkenoyloxy, alkynoyloxy, alkanoyloxymethyl, alkenoyloxymethyl, alkynoyloxymethyl, alkoxymethyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkylsulfonamido, alkenylsulfonamido, alkynylsulfonamido, hydroxy, trifluoromethyl, cyano, nitro, carboxy, carboalkoxy, carboalkyl, phenoxy, phenyl, thiophenoxy, benzyl, amino, hydroxyamino, alkoxyamino, alkylamino, dialkylamino, aminoalkyl, N-alkylaminoalkyl, N,N-dialkylaminoalkyl, phenylamino, benzylamino, formulae (a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p, q or r); R5 is alkyl which may be optionally substituted, or phenyl which may be optionally substituted; R6 is hydrogen, alkyl, or alkenyl; R7 is chloro or bromo; R8 is hydrogen, alkyl, aminoalkyl, N-alkylaminoalkyl, N,N-dialkylaminoalkyl, N-cycloalkylaminoalkyl, N-cycloalkyl-N-alkylaminoalkyl, N,N-dicycloalkylaminoalkyl, morpholino-N-alkyl, piperidino-N-alkyl, N-alkyl-piperidino-N-alkyl, azacycloalkyl-N-alkyl, hydroxyalkyl, alkoxyalkyl, carboxy, carboalkoxy, phenyl, carboalkyl +, chloro, fluoro, or bromo; Z is amino, hydroxy, alkoxy, alkylamino, dialkylamino, morpholino, piperazino, N-alkylpiperazino, or pyrrolidino; m = 1-4, q = 1-3, and p = 0-3; any of the substituents R1, R2, R3 or R4 that are located on contiguous carbon atoms can together be the divalent radical -O-C(R8)2-O-; or a pharmaceutically acceptable salt thereof with the proviso that when Y is -NH-, R1, R2, R3 and R4 are hydrogen, and n is O, X is not 2-methylphenyl, which are inhibitors of protein tyrosine kinase.