113302-88-8

Basic information

• Product Name: 1H-Indazole, 5-Methyl-7-nitro-
• Synonyms: 1H-Indazole, 5-Methyl-7-nitro-;5-Methyl-7-nitro-1H-indazole
• CAS NO: 113302-88-8
• Molecular Formula: C8H7N3O2
• Molecular Weight: 177.16008
• EINECS: -0
• Mol File: 113302-88-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 191-192 °C
• Boiling Point: 397.2±22.0 °C(Predicted)
• Appearance: /
• Density: 1.437±0.06 g/cm3(Predicted)
• PKA: 10.25±0.40(Predicted)
• CAS DataBase Reference: 1H-Indazole, 5-Methyl-7-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indazole, 5-Methyl-7-nitro-(113302-88-8)
• EPA Substance Registry System: 1H-Indazole, 5-Methyl-7-nitro-(113302-88-8)

Safety Data

• Hazardous Substances Data: 113302-88-8(Hazardous Substances Data)

Usage

General Description

1H-Indazole, 5-methyl-7-nitro- is a chemical compound that belongs to the indazole class of heterocyclic compounds. It is a derivative of indazole that contains a methyl group at the 5th position and a nitro group at the 7th position. 1H-Indazole, 5-methyl-7-nitro- has potential applications in the pharmaceutical industry, particularly in the development of new drugs and medicines. Its unique structure and properties make it a valuable tool for research and experimentation in the field of organic chemistry and drug discovery. The nitro group in the molecule makes it a potential candidate for further functionalization and modification, leading to the development of novel compounds with various biological activities and pharmaceutical capabilities.

Upstream product

• 1635-84-3 2,4-Dimethyl-6-nitroanilin 
• 7782-77-6 cis-nitrous acid 
• 66620-31-3 2-hydroxy-5-methyl-3-nitro-benzaldehyde 
• 95-68-1 2,4-Xylidine 
• 113302-82-2 Toluene-4-sulfonate1-(2-formyl-4-methyl-6-nitro-phenyl)-pyridinium; 
• 113302-69-5 2-azido-5-methyl-3-nitrobenzaldehyde azine 
• 113302-64-0 2-azido-5-methyl-3-nitrobenzaldehyde 
• 613-84-3 2-hydroxy-5-methylbenzaldehyde 
• 7647-01-0 hydrogenchloride 
• 71-43-2 benzene 
• 124-41-4 sodium methylate 
• 113302-74-2 5,5'-dimethyl-7,7'-dinitro-2,2'-biindazole 

Downstream Products

• 113302-96-8 7-amino-5-methylindazole 
• 861326-01-4 (5-methyl-1⁽²⁾H-indazol-7-yl)-(4-nitro-benzyliden)-amine 
• 871886-57-6 N-(5-methyl-1(2)H-indazol-7-yl)-acetamide 

Relevant articles and documents

TYK2 INHIBITORS AND USES THEREOF

Described herein are compounds that are useful in treating a TYK2-mediated disorder. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a disorder associated with transplantation.

INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS

The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.

Synthesis and Complexing Properties of Macrocycles Incorporating 2,2'-Biindazolyl Binding Subunits

Substituted 2,2'-biindazoles 4 and 19-23 were prepared in 80-90percent yields by thermal decomposition of o,o'-diazido azines 13-18, which in turn were readily obtained from the corresponding 2-azidobenzaldehydes or 2-azidobenzophenones.The preference of