113345-85-0

Upstream product

• 53015-08-0 2-formyl-6-methoxy-benzoic acid 
• 3462-97-3 (4-methoxybenzyl)triphenylphosphonium bromide 
• 82780-51-6 (+/-)-3-(4-methoxyphenyl)-8-methoxy-3,4-dihydroisocoumarin 
• 123-11-5 4-methoxy-benzaldehyde 
• 142819-35-0 7-methoxy-3H-benzo[c]thiophen-1-one 

Downstream Products

• 52213-49-7 (+/-)-3-(4-methoxyphenyl)-8-hydroxy-3,4-dihydroisocoumarin 
• 36640-14-9 2-Methoxy-6-<2-(4-methoxyphenyl)ethyl>benzoic acid 
• 82780-51-6 (+/-)-3-(4-methoxyphenyl)-8-methoxy-3,4-dihydroisocoumarin 
• 183619-63-8 7-Methoxy-3-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-3H-isobenzofuran-1-one 
• 113345-84-9 methyl 2-methoxy-6-[2-(4-methoxyphenyl)ethenyl]benzoate 
• 80458-94-2 3'-Deoxythunberginol A 
• 36640-12-7 3-(4-methoxyphenyl)-7-methoxy-2-benzopyran-1(1H)-one 

Relevant academic research and scientific papers

Stereoselective synthesis of hydroxy stilbenoids and styrenes by atom-efficient olefination with thiophthalides

The synthesis of stilbenoids and styryl carboxylic acids is accomplished with high E-stereoselectivity by olefination of aldehydes with thiophthalides under basic conditions. The olefination is highly atom-efficient as it only loses elemental sulfur during the reaction. This olefination, in conjunction with retro Kolbe-Schmitt reaction, allows facile synthesis of E-hydroxystilbenoids with minimal employment of protecting groups. This study also discloses two important findings: formation of i) 4-methylsulfanyl isocoumarins and ii) an 2-arylindenone. The Royal Society of Chemistry 2012.

Convenient syntheses of 3-aryl-3,4-dihydroisocoumarins and lunularic acid derivatives

A convenient two-step approach for the syntheses of 3-aryl-3,4-dihydroisocoumarins (13-17) including some naturally occurring 3-aryl-8-hydroxy-3,4-dihydroisocoumarins (1,2) and lunularic acid derivatives (18-21) is described from 2-formylbenzoic acids (4,