113454-58-3

Upstream product

• 113258-90-5 4-hydroxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 108960-88-9 2-methyl-4-phenylisoquinolin-1(2H)-one 
• 79841-13-7 2-methyl-2,3-dihydroisoquinolin-4(1H)-one 
• 1531-78-8 o-(chloromethyl)benzoic acid ethyl ester 
• 188440-97-3 2-[(ethoxycarbonylmethyl-methyl-amino)-methyl]-benzoic acid ethyl ester 
• 19571-30-3 4-phenylisoquinoline 
• 1298108-49-2 2-methyl-4-phenylisoquinolinium iodide 
• 175857-53-1 N-diphenylphosphinoylmethyl-N-methyl-2-benzoylbenzamide 
• 100372-65-4 2-methyl-4-oxo-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ethyl ester 

Downstream Products

• 28102-51-4 1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline 
• 1298108-51-6 C₁₇H₁₆F₃N 
• 1298108-50-5 2-methyl-4-phenyl-1-trifluoromethyl-1,2-dihydroisoquinoline 

Relevant academic research and scientific papers

Synthesis of CF3-substituted 1,2,3,4-tetrahydroisoquinolines and 1,2,3,6-tetrahydropyridines

A three-step method for the preparation of CF3-substituted 1,2,3,4-tetrahydroisoquino-lines and 1,2,3,6-tetrahydropyridines has been suggested. The first step includes alkylation of isoquinoline or 4-methylpyridine at the nitrogen atom with the

New reduction reaction of benzylic alcohols with acid and proof of the intermolecular hydride shift mechanism

The new reduction reaction of the hydroxy groups of 4-hydroxy-4-phenyl- 1,2,3,4-tetrahydroisoquinolines (1) to the corresponding alkanes (2) with mineral and Lewis acids is reported. A stereoselective intermolecular hydride shift mechanism of the reduction was proved by reaction of the deuterated derivatives (14 and 15) of 1a with 10N HCl-C2H5OH and BBr3 in CH3CN.

Stereoselective intermolecular hydride shift mechanism of the new reduction of benzylic alcohols with acid

A stereoselective intermolecular hydride shift mechanism of the new reduction reaction of the benzylic hydroxy group of 4-hydroxy-4-phenyl-1,2,3,4-tetrahydroisoquinoline (1) to the corresponding alkane (2) with acid was proved by reaction of the deuterated derivatives (5 and 6) of 1.

A new synthetic route to 2-alkyl-4-aryl-1(2H)-isoquinolones and 2-alkyl-4-aryl-1,2,3,4-tetrahydroisoquinolines

4-Aryl and heteroaryl-1(2H)-isoquinolones have been prepared by base promoted cyclization of phosphorylated o-aroyl and heteroaroyl benzamides. Subsequent reduction of the carbonyl and styryl functions of the annulated products has given rise to 4-aryl-1,2,3,4-tetrahydroisoquinolines.