28102-51-4

Basic information

• Product Name: (4S*)-N-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline
• Synonyms: (4S*)-N-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 28102-51-4
• Molecular Weight: 223.318
• Mol File: 28102-51-4.mol
• Article Data: 24

Chemical Properties

• CAS DataBase Reference: (4S*)-N-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: (4S*)-N-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline(28102-51-4)
• EPA Substance Registry System: (4S*)-N-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline(28102-51-4)

Safety Data

• Hazardous Substances Data: 28102-51-4(Hazardous Substances Data)

Upstream product

• 110841-22-0 2-methyl-4-phenyl-1,2,3,4-tetrahydro-1(2H)-isoquinolone 
• 50-00-0 formaldehyd 
• 75626-12-9 4-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 21921-91-5 2-Benzyl-N-methyl-benzamid 
• 3947-77-1 2-methylisoquinolinium iodide 
• 1612-65-3 2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 108-90-7 chlorobenzene 
• 100-52-7 benzaldehyde 
• 51096-49-2 2-benzylamino-1-phenyl-ethanol 
• 290347-03-4 (4S*)-N-[(R)-2-hydroxy-1-phenylethyl]-4-phenyl-1,4-dihydroisoquinolin-3-one 
• 290347-00-1 (4S*)-N-[(R)-2-hydroxy-1-phenylethyl]-4-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 290346-99-5 N-[(R)-2-hydroxy-1-phenylethyl]-4-phenyl-1,4-dihydroisoquinolin-3-one 
• 612-35-1 2-Benzylbenzoic acid 
• 1586-00-1 2-(benzyl)benzyl alcohol 

Downstream Products

• 1057137-26-4 2-(4-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)acetonitrile 
• 213842-75-2 (R)-N-methyl-4-(phenyldeuterio)-1,2,3,4-tetrahydroisoquinoline 1-d1 

Relevant articles and documents

Synthesis of 6,12-Methanodibenzo[ c, f]azocines and 4-Aryltetrahydroisoquinolines from Aromatic Aldehydes

A methodology for the synthesis of 7,12-dihydro-5H-6,12-methanodibenzo[c,f]azocines from aromatic aldehydes and N-(methoxymethyl)-N-(trimethylsilylmethyl)benzylamine using catalysis by trifluoroacetic and perchloric acids is described. The developed protocol was applied for the synthesis of N-unsubstituted and N-methyl-4-aryltetrahydroisoquinolines.

Zinc-Catalyzed Alkyne Oxidation/C-H Functionalization: Highly Site-Selective Synthesis of Versatile Isoquinolones and β-Carbolines

An efficient zinc(II)-catalyzed alkyne oxidation/C￡H functionalization sequence was developed, thus leading to highly site-selective synthesis of a variety of isoquinolones and β-carbolines. Importantly, in contrast to the well-established gold-catalyzed intermolecular alkyne oxidation, over-oxidation can be completely suppressed in this system and the reaction most likely proceeds by a Friedel-Crafts-type pathway. Mechanistic studies and theoretical calculations are described.

4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors

Novel 4-phenyl tetrahydroisoquinolines that inhibit both dopamine and norepinephrine transporters were designed and prepared. In this Letter, we describe the synthesis, in vitro activity and associated structure-activity relationships of this series. We also report the ex vivo NET occupancy of a representative compound, 41.