1184103-00-1Relevant articles and documents
Novel pyrazolopyrimidines as highly potent B-Raf inhibitors
Di Grandi, Martin J.,Berger, Dan M.,Hopper, Darrin W.,Zhang, Chunchun,Dutia, Minu,Dunnick, Alejandro L.,Torres, Nancy,Levin, Jeremy I.,Diamantidis, George,Zapf, Christoph W.,Bloom, Jonathan D.,Hu, YongBo,Powell, Dennis,Wojciechowicz, Donald,Collins, Karen,Frommer, Eileen
scheme or table, p. 6957 - 6961 (2010/06/19)
A novel series of pyrazolo[1,5-a]pyrimidines bearing a 3-hydroxyphenyl group at C(3) and substituted tropanes at C(7) have been identified as potent B-Raf inhibitors. Exploration of alternative functional groups as a replacement for the C(3) phenol demons
FUSED TRICYCLIC PYRAZOLO[1, 5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF
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, (2009/10/21)
Fused, tricyclic pyrazolo{1,5-a]pyrimidine compounds of formula A or of formula B: and pharmaceutically acceptable salts thereof are described, which selectively inhibit Raf kinase activity and are useful for treating disorders mediated by certain Raf kinases.