1184103-48-7

Basic information

• Product Name: 2-(4-chloro-3-methoxyphenyl)-3-oxo-3-pyridin-4-ylpropanenitrile
• Synonyms: 2-(4-chloro-3-methoxyphenyl)-3-oxo-3-pyridin-4-ylpropanenitrile
• CAS NO: 1184103-48-7
• Molecular Weight: 286.718
• Mol File: 1184103-48-7.mol

Chemical Properties

• CAS DataBase Reference: 2-(4-chloro-3-methoxyphenyl)-3-oxo-3-pyridin-4-ylpropanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chloro-3-methoxyphenyl)-3-oxo-3-pyridin-4-ylpropanenitrile(1184103-48-7)
• EPA Substance Registry System: 2-(4-chloro-3-methoxyphenyl)-3-oxo-3-pyridin-4-ylpropanenitrile(1184103-48-7)

Safety Data

• Hazardous Substances Data: 1184103-48-7(Hazardous Substances Data)

Upstream product

• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 13726-21-1 2-(4-chloro-3-methoxyphenyl)acetonitrile 

Downstream Products

• 1184103-49-8 3-chloro-2-(4-chloro-3-methoxyphenyl)-3-pyridin-4-ylacrylonitrile 
• 1184103-08-9 12-benzyl-3-(4-chloro-3-methoxyphenyl)-8-(phenylsulfonyl)-2-pyridin-4-yl-7,8,9,10-tetrahydro-6H-7,10-epiminocyclohepta[e]pyrazolo[1,5-a]pyrimidine 
• 1184103-00-1 2-chloro-5-[12-methyl-8-(phenylsulfonyl)-2-pyridin-4-yl-7,8,9,10-tetrahydro-61-1-7,10-epiminocyclo-hepta[e]pyrazolo[1,5-a]pyrimidin-3-yl]phenol 
• 1184103-03-4 methyl 3-(4-chloro-3-hydroxyphenyl)-12-methyl-2-pyridin-4-yl-7,8,9,10-tetrahydro-6H-7,10-epiminocyclohepta-[e]pyrazolo[1,5-a]pyrimidine-8-carboxylate 
• 1184103-06-7 2-chloro-5-[8-(hydroxymethyl)-12-methyl-2-pyridin-4-yl-7,8,9,10-tetrahydro-6H-7,10-epiminocyclo-hepta[e]pyrazolo[1,5-a]pyrimidin-3-yl]phenol 
• 1134598-81-4 5-(3-amino-5-pyridin-4-yl-1H-pyrazol-4-yl)-2-chlorophenol 
• 1134598-79-0 4-(4-chloro-3-methoxyphenyl)-5-pyridin-4-yl-1H-pyrazol-3-amine 

Relevant articles and documents

FUSED TRICYCLIC PYRAZOLO[1, 5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF

Fused, tricyclic pyrazolo{1,5-a]pyrimidine compounds of formula A or of formula B: and pharmaceutically acceptable salts thereof are described, which selectively inhibit Raf kinase activity and are useful for treating disorders mediated by certain Raf kinases.

Discovery of highly potent and selective type I B-Raf kinase inhibitors

A series of pyrazolo[1,5-α]pyrimidine analogs has been prepared and found to be potent and selective B-Raf inhibitors. Molecular modeling suggests they bind to the active conformation of the enzyme.