1137-11-7

Upstream product

• 67-51-6 3,5-dimethyl-1H-pyrazole 
• 98-88-4 benzoyl chloride 
• 64-17-5 ethanol 
• 613-94-5 benzoic acid hydrazide 
• 123-54-6 acetylacetone 
• 93-97-0 benzoic acid anhydride 
• 4335-90-4 3-benzylidene acetylacetone 
• 1452-58-0 benzoic hydrazide hydrochloride 
• 98-07-7 Benzotrichlorid 

Downstream Products

• 100-52-7 benzaldehyde 
• 67-51-6 3,5-dimethyl-1H-pyrazole 
• 14164-34-2 4,6-dimethyl-2-phenylpyrimidine 
• 1565-71-5 3-phenylpentan-3-ol 
• 93-55-0 1-phenyl-propan-1-one 
• 98-86-2 acetophenone 
• 98-83-9 isopropenylbenzene 
• 134-84-9 4-Methylbenzophenone 
• 6266-56-4 bis(4-methylphenyl)phenylmethanol 
• 119-61-9 benzophenone 
• 76-84-6 triphenylmethyl alcohol 
• 913184-66-4 bis(3,5-dimethylpyrazole)bis(benzoato)copper(II) monohydrate 
• 1131-16-4 3,5-dimethyl-1-phenyl-1H-pyrazole 
• 13358-49-1 1-phenylethyl benzoate 

Relevant academic research and scientific papers

Solventless synthesis of poly(pyrazolyl) phenyl-methane ligands and thermal transformation of tris(3,5-dimethylpyrazol-1-yl)phenylmethane

The solventless synthesis of tris(pyrazolyl)phenylmethane ligands of formula C6H5C(PzR2)3 (R = H, Me), starting from PhCCl3 and 3,5-dimethylpyrazole (PzMe2) or pyrazole (Pz) was performed.

Iodonium salts as efficient iodine(iii)-based noncovalent organocatalysts for Knorr-type reactions

Hypervalent iodine(iii)-derivatives display higher catalytic activity than other aliphatic and aromatic iodine(i)- or bromine(i)-containing substrates for a Knorr-type reaction of N-acetyl hydrazides with acetyl acetone to give N-acyl pyrazoles. The highe

Predicting the catalytic activity of azolium-based halogen bond donors: an experimentally-verified theoretical study

This report demonstrates the successful application of electrostatic surface potential distribution analysis for evaluating the relative catalytic activity of a series of azolium-based halogen bond donors. A strong correlation (R2> 0.97) was observed between the positive electrostatic potential of the σ-hole on the halogen atom and the Gibbs free energy of activation of the model reactions (i.e., halogen abstraction and carbonyl activation). The predictive ability of the applied approach was confirmed experimentally. It was also determined that the catalytic activity of azolium-based halogen bond donors was generally governed by the structure of the azolium cycle, whereas the substituents on the heterocycle had a limited impact on the activity. Ultimately, this study highlighted four of the most promising azolium halogen bond donors, which are expected to exhibit high catalytic activity.

Synthesis of quinoxaline, benzimidazole and pyrazole derivatives under the catalytic influence?of biosurfactant-stabilized iron nanoparticles in water

Abstract: We have reported the synthesis, characterization, and catalytic applications of amorphous iron nanoparticles (FeNPs) using aqueous leaves extract of renewable natural resource Boswellia serrata plant. Synthesized FeNPs were stabilized in situ by the addition of aqueous pod extracts of Acacia concinna as a biosurfactant (pH 3.11). The structural investigation of biosynthesized nanoparticles was performed using UV–visible spectroscopy, X-ray diffraction analysis, selected area electron diffraction, energy-dispersive X-ray spectroscopy, scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, thermogravimetric analysis, and BET analysis. The FeNPs were amorphous in nature with average particle size ~ 19?nm and successfully employed as heterogeneous catalyst for the synthesis of quinoxaline, benzimidazole, and pyrazole derivatives in aqueous medium at ambient conditions. The FeNPs could be recycled up to five times with modest change in the catalytic activity. Graphic abstract: [Figure not available: see fulltext.].

Structural characterization of benzoyl-1H-pyrazole derivatives obtained in lemon juice medium: Experimental and theoretical approach

Simple, one-pot, and low-cost reactions of acetylacetone with a variety of substituted benzoyl hydrazides in lemon juice, as eco-friendly medium, were performed. In reactions of benzoyl hydrazides with electron-donating groups on phenyl ring, the 1-benzoy

Cu1.5PMo12O40-catalyzed condensation cyclization for the synthesis of substituted pyrazoles

A convenient and direct approach has been developed for the preparation of pyrazole derivatives by the condensation cyclization of hydrazines/hydrazide and 1,3-diketones in the presence of Cu1.5PMo12O40 (0.33?mol%) under mild conditions (r.t.-60?°C, 10–30?min). Notably, the reaction was found to be scalable as 99% yield was obtained when the reaction was performed at a 5-mmol scale. This solvent-free and halogen-free catalytic system represents an effective economic and environmentally friendly method for the construction of pyrazoles.

Electronic effects on the structures and catalytic properties of (pyrazol-1-yl)phenylmethanone palladium(II) complexes

Four new (pyrazol-1-yl)phenylmethanone ligands and their palladium(II) complexes were synthesized and characterized by various analytical techniques. The electronic properties of substituents on the phenyl ring of the ligand have significant effects on th

Copper-catalyzed C–N cross-coupling of arylboronic acids with N-acylpyrazoles

A copper-catalyzed C–N bond forming reaction of arylboronic acids and N-acylpyrazoles was developed. This procedure used N-acetyl protected pyrazoles as starting material instead of free pyrazoles (NH). The reaction worked under neutral conditions and did not require any base or ligand. The reaction showed good functional group tolerance.

A green protocol for catalyst-free syntheses of pyrazole in glycerol-water solution

An efficient green protocol for preparing pyrazole derivatives using glycerol and water as a mixture solvent is described. The advantages of the present method lie in using economic and environmentally benign solvent, no use of catalyst, mild reaction conditions and good yields.

An efficient practical chemo-enzymatic protocol for the synthesis of pyrazoles in aqueous medium at ambient temperature

An expeditious oxidative cyclocondensation reaction of hydrazines/hydrazides with 1,3-dicarbonyl compound was efficiently developed in aqueous medium using Saccharomyces cerevisae (baker's yeast) as a whole cell biocatalyst at room temperature. The method has been assigned using green chemistry measures and found to give a range of N-substituted pyrazoles with moderate to excellent yields (70-92%). The reaction progress was monitored by gas chromatography.