113771-58-7

Basic information

• Product Name: Methyl chromane-2-carboxylate
• Synonyms: Methyl chromane-2-carboxylate;METHYL CHROMAN-2-CARBOXYLATE
• CAS NO: 113771-58-7
• Molecular Formula: C₁₁H₁₂O₃
• Molecular Weight: 192.21118
• Mol File: 113771-58-7.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl chromane-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl chromane-2-carboxylate(113771-58-7)
• EPA Substance Registry System: Methyl chromane-2-carboxylate(113771-58-7)

Safety Data

• Hazardous Substances Data: 113771-58-7(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 51939-71-0 chroman-2-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 56052-43-8 2-(2-Benzyloxyphenyl)ethanol 
• 179253-16-8 2-(2-(benzyloxy)phenyl)acetaldehyde 
• 5896-17-3 2-(phenylmethoxy)benzaldehyde 
• 4940-39-0 acide chromone carboxylique-2 

Downstream Products

• 3990-58-7 chroman-2-ylcarboxamide 
• 149177-75-3 (2R)-3,4-dihydro-2H-chromen-2-ylmethylamine hydrochloride 
• 227466-91-3 (R)-chroman-2-carboxylic acid chloride 
• 404337-71-9 (-)-(R)-3,4-dihydro-2H-1-benzopyran-2-methanamine 
• 955124-60-4 (R)-tert-butyl (8-(2,6-dichlorophenyl)-2-chromanyl)methylcarbamate 
• 83278-86-8 3,4-dihydro-2H-1-benzopyran-2-methanol 

Relevant articles and documents

Meta C-H Arylation of Electron-Rich Arenes: Reversing the Conventional Site Selectivity

Controlling site selectivity of C-H activation without using a directing group remains a significant challenge. While Pd(II) catalysts modulated by a mutually repulsive pyridine-type ligand have been shown to favor the relatively electron-rich carbon centers of arenes, reversing the selectivity to favor palladation at the relatively electron-deficient positions has not been possible. Herein we report the first catalytic system that effectively performs meta C-H arylation of a variety of alkoxy aromatics including 2,3-dihydrobenzofuran and chromane with exclusive meta site selectivity, thus reversing the conventional site selectivity governed by native electronic effects. The identification of an effective ligand and modified norbornene (NBE-CO2Me), as well as taking advantage of the statistics, are essential for achieving the exclusive meta selectivity.

An efficient and practical enantiospecific synthesis of methyl chromanone- and chroman-2-carboxylates

Chromanone-2-carboxylates and chroman-2-carboxylates are useful building blocks for the synthesis of a variety of bioactive compounds, such as repinotan, fidarestat, and nebivolol. An efficient and practical enantiospecific synthesis of chromanone-2-carboxylates and chroman-2-carboxylates has been accomplished using intramolecular Mitsunobu etherification of methyl (S)-2-hydroxy-4-oxo-4-(2′-hydroxy)phenylbutanoates derived from l-malic acid.

New Somatostatin receptor subtype 4 (SSTR4) agonists

3-aza-bicyclo[3.1.0]hexane-6-carboxylic acid amide derivatives which are agonists of somatostatin receptor subtype 4 (SSTR4), useful for preventing or treating medical disorders related to SSTR4.