1137726-89-6

Upstream product

• 64-17-5 ethanol 
• 1137726-90-9 ((1S,4S,5S)-4-acetamido-5-(tert-butoxycarbonylamino)cyclohex-2-enyl)dicyanomethyl acetate 
• 1184177-24-9 tert-butyl (1S,2S,5S)-2-acetamido-5-((tert-butyldimethylsilyloxy)dicyanomethyl)cyclohex-3-enylcarbamate 
• 1184177-26-1 tert-butyl (3aS,4R,5S,7S,7aR)-4-acetamido-7-((tert-butyldimethylsilyloxy)dicyanomethyl)-2,2-dimethyl-hexahydrobenzo[d][1,3]dioxol-5-ylcarbamate 
• 1224161-51-6 ethyl (3aR, 4R,6S,7R,7aS)-7-acetamido-6-amino-2,2-dimethylhexahydrobenzo[d][1,3]dioxole-4-carboxylate 
• 1224161-50-5 (3aR,7R,7aS)-ethyl-7-acetamido-6-(hydroxyimino)-2,2-dimethyl-3a,6,7,7a-tetrahydrobenzo[d][1,3]dioxole-4-carboxylate 
• 1224161-49-2 (3aR,7S,7aS)-ethyl-7-acetamido-2,2-dimethyl-6-oxo-3a,6,7,7a-tetrahydrobenzo[d]-[1,3]dioxole-4-carboxylate 
• 1173701-24-0 ethyl (3aS,4S,7R,7aS)-7-(acetylamino)-4-hydroxy-2,2-dimethyl-3a,4,7,7a-tetrahydro-1,3-benzodioxole-4-carboxylate 
• 1173701-23-9 (1R,2S,6S,7S)-9-acetyl-4,4-dimethyl-3,5,8-trioxa-9-aza-tricyclo[5.2.2.0.2.6]undec-10-ene-7-carboxylic acid ethyl ester 
• 1185040-54-3 (+)-ethyl (3aR,7aS)-2,2-dimethyl-3a,7a-dihydrobenzo[d][1,3]dioxole-4-carboxylate 
• 1173701-22-8 (+)-ethyl (5S,6R)-5,6-dihydroxycyclohexa-1,3-dienecarboxylate 
• 93-89-0 benzoic acid ethyl ester 
• 1224161-52-7 (3aR,6S,7R,7aS)-7-acetylamino-6-tert-butoxycarbonylamino-2,2-dimethyl-3a,6,7,7a-tetrahydrobenzo[1,3]dioxole-4-carboxylic acid ethyl ester 

Downstream Products

• 367252-68-4 (3R,4R,5S)-ethyl 4-acetamido-5-((tert-butoxycarbonyl)amino)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate 

Relevant academic research and scientific papers

PROCESS AND COMPOUNDS FOR THE MANUFACTURE OF OSELTAMIVIR AND ANALOGS THEREOF, AND NEW ANTIVIRAL AGENTS

The present application relates to processes for the preparation of intermediates useful in the manufacture of oseltamivir and the H3PO4 salt of oseltamivir, Tamiflu?. The application further relates to novel intermediate and compoun

Several generations of chemoenzymatic synthesis of oseltamivir (Tamiflu): Evolution of strategy, quest for a process-quality synthesis, and evaluation of efficiency metrics

Four generations of chemoenzymatic approaches to oseltamivir are presented. The first two generations relied on the use of cyclohexadiene-cis-diol derived enzymatically from bromobenzene. The third and fourth generation used the corresponding diol obtaine

Short chemoenzymatic azide-free synthesis of oseltamivir (tamiflu): Approaching the potential for process efficiency

A short chemoenzymatic and azide-free synthesis of oseltamivir was attained with the key steps consisting of a one-pot Dauben-Michno oxidative transposition and animation and a reductive transposition of an acrylate.

An alternative synthesis of Tamiflu: a synthetic challenge and the identification of a ruthenium-catalyzed dihydroxylation route

Synthetic studies of Tamiflu and the identification of a ruthenium-catalyzed dihydroxylation route are disclosed. This newly developed synthetic process circumvents the need for a Mitsunobu inversion step and the use of explosive reagents. This

A synthesis of tamiflu by using a barium-catalyzed asymmetric diels-alder-type reaction

(Chemical Equation Presented) In pursuit of a better route: A new catalytic asymmetric synthesis of Tamiflu was developed. The key transformation was an asymmetric Diels-Alder-type reaction of 1 and 2 catalyzed by a barium/F 2-FujiCAPO complex in the presence of a CsF co-catalyst to construct the core of Tamiflu (see scheme; TMS=trimethylsilyl). The product was converted into Tamiflu in 11 steps on a gram scale.