113787-28-3 Usage
Uses
Used in Pharmaceutical Industry:
L-659989 is used as a PAF receptor antagonist for its cardioprotective properties, specifically in the prevention of heart injury caused by ischemia and reperfusion in rats. This makes it a potential candidate for the development of treatments targeting heart conditions and related complications.
Additionally, L-659989's ability to inhibit phospholipase D activity at higher concentrations may have implications in other therapeutic areas, such as inflammation and other diseases where phospholipase D plays a significant role. Further research would be required to explore these potential applications.
Check Digit Verification of cas no
The CAS Registry Mumber 113787-28-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,7,8 and 7 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 113787-28:
(8*1)+(7*1)+(6*3)+(5*7)+(4*8)+(3*7)+(2*2)+(1*8)=133
133 % 10 = 3
So 113787-28-3 is a valid CAS Registry Number.
113787-28-3Relevant academic research and scientific papers
ENANTIOSELECTIVE CYCLIZATION OF CHIRAL BUTANE-1,4-DIOLS TO CHIRAL TETRAHYDROFURANS: SYNTHESIS OF CHIRAL TRANS-2-(3-METHOXY-5-METHYLSULFONYL-4-PROPOXYPHENYL-5-(3,4,5-TRIMETHOXYPHENYL)TETRAHYDROFURAN (L-659,989), A POTENT PAF-RECEPTOR ANTAGONIST
Ponpipom, M. M.,Bugoanesi, R. L.,Chabala, J. C.
, p. 6211 - 6214 (2007/10/02)
Acid catalyzed cyclization of (1R,4RS)- and(1S,4RS)-1-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-4-(3,4,5-trimethoxyphenyl)butane-1,4-diols to the corresponding chiral cis- and trans-tetrahydrofurans proceeds with retention of configuration at C-1.Using
