113790-67-3

Upstream product

• 1136-86-3 methyl (3,4,5-trimethoxyphenyl) ketone 
• 5438-36-8 5-iodovaniline 
• 106331-91-3 1-(3-methoxy-5-methylthio-4-n-propoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-butanedione 
• 60-29-7 diethyl ether 

Downstream Products

• 116681-60-8 (1R,4RS)-1-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-4-(3,4,5-trimethoxyphenyl)butane-1,4-diol 
• 116681-60-8 (1R,4RS)-1-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-4-(3,4,5-trimethoxyphenyl)butane-1,4-diol 
• 116681-64-2 (S)-4-Hydroxy-4-(3-methanesulfonyl-5-methoxy-4-propoxy-phenyl)-1-(3,4,5-trimethoxy-phenyl)-butan-1-one 
• 116681-65-3 (R)-4-Hydroxy-4-(3-methanesulfonyl-5-methoxy-4-propoxy-phenyl)-1-(3,4,5-trimethoxy-phenyl)-butan-1-one 
• 116781-16-9 (+)-L 659989 
• 121702-59-8 (5S,2R)-2-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 
• 106331-88-8 (2S,5R)-2-(3-Methanesulfonyl-5-methoxy-4-propoxy-phenyl)-5-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan 
• 106331-88-8 (2S,5S)-2-(3-Methanesulfonyl-5-methoxy-4-propoxy-phenyl)-5-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan 
• 129314-27-8 trans-2-(3-methoxy-5-methylsulfonyl-4-n-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 
• 121702-60-1 L 662418 
• 116781-15-8 (-)-L 659989 
• 116681-60-8 1-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-butanediol 
• 116681-62-0 4-Hydroxy-4-(3-methanesulfonyl-5-methoxy-4-propoxy-phenyl)-1-(3,4,5-trimethoxy-phenyl)-butan-1-one 

Relevant academic research and scientific papers

ENANTIOSELECTIVE CYCLIZATION OF CHIRAL BUTANE-1,4-DIOLS TO CHIRAL TETRAHYDROFURANS: SYNTHESIS OF CHIRAL TRANS-2-(3-METHOXY-5-METHYLSULFONYL-4-PROPOXYPHENYL-5-(3,4,5-TRIMETHOXYPHENYL)TETRAHYDROFURAN (L-659,989), A POTENT PAF-RECEPTOR ANTAGONIST

Acid catalyzed cyclization of (1R,4RS)- and(1S,4RS)-1-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-4-(3,4,5-trimethoxyphenyl)butane-1,4-diols to the corresponding chiral cis- and trans-tetrahydrofurans proceeds with retention of configuration at C-1.Using

2-Aryl-5(3-methoxy-5-(hydroxypropylsulfonyl)-4-propoxyphenyl) tetrahydrothiophen and analogs

Analogs of 2-aryl-5-3-Methoxy-5-(2-hydroxy-propylsulfonyl)-4-propoxyphenyl)tetrahydrothiophene were prepared. These compounds are found to be leukotriene inhibitors and potent and specific PAF (Platelet Activating Factor) antagonists. They are therefore u