ENANTIOSELECTIVE CYCLIZATION OF CHIRAL BUTANE-1,4-DIOLS TO CHIRAL TETRAHYDROFURANS: SYNTHESIS OF CHIRAL TRANS-2-(3-METHOXY-5-METHYLSULFONYL-4-PROPOXYPHENYL-5-(3,4,5-TRIMETHOXYPHENYL)TETRAHYDROFURAN (L-659,989), A POTENT PAF-RECEPTOR ANTAGONIST

DOI: 10.1016/S0040-4039(00)82307-2

Source and publish data:

Tetrahedron Letters p. 6211 - 6214 (1988)

Update date:2022-08-03

Topics:

Authors:

Ponpipom, M. M.

Bugoanesi, R. L.

Chabala, J. C.

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Article abstract of DOI:10.1016/S0040-4039(00)82307-2

Acid catalyzed cyclization of (1R,4RS)- and(1S,4RS)-1-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-4-(3,4,5-trimethoxyphenyl)butane-1,4-diols to the corresponding chiral cis- and trans-tetrahydrofurans proceeds with retention of configuration at C-1.Using

Full text of DOI:10.1016/S0040-4039(00)82307-2

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